Alkaline Phosphatase FS (IFCC mod. 37°C)
Alkaline phosphatase (AP) is a membrane-bound enzyme all tissue express. With its cofactors zinc and magnesium, AP catalyzes the hydrolysis of organic phosphate esters in the extracellular space. AP is present in the blood in various forms, primarily from the bone and liver, but also from other tissues such as the kidneys, placenta, testes, thymus, lungs, and tumors. Increased AP activity can occur physiologically, for example, during the second trimester of pregnancy and in children during growth. Pathological conditions that cause increased AP activity include hepatobiliary diseases, skeletal system diseases, malignant tumors, and systemic diseases without primary involvement of the liver or bones. Decreased AP activity in serum is infrequent, and when present, is associated with hereditary hypophosphatasia, Wilson's disease, and corticosteroid-induced osteoporosis.
- Intrahepatic cholestasis, (example: liver infiltrates by carcinoma, leukemia, tuberculosis, sarcoidosis, amyloidosis, fibrosis (cirrhosis))
- Extrahepatic cholestasis (eg, bile duct stones, neoplasms, atresia)
- Osteoblastic disease, (eg malignancy, secondary hyperparathyroidism, Paget's disease)
- Tumor
- Pregnancy
- Hypophosphatasemia: a relatively rare inherited disorder that is asymptomatic or may be associated with arthritis of the weight-bearing joints
- Hypothyroidism
- Scurvy
- Severe anemia
Proline Alkaline Phosphatase FS (IFCC mod. 37°C) comes in a liquid format which provides convenience for users as no reconstitution is required which helps reduce the risk of misdiagnosis.
Proline Alkaline Phosphatase FS (IFCC mod. 37°C) reagent is suitable for various third party analyzers such as Abbott, Advia, Cobas, Hitachi, Olympus, Response, TokyoBoeki, and Beckman Coulter. Please contact our technical support at marketing@proline.co.id for further compatibility information on other types of analyzers.
- Kinetic photometric tests according to IFCC (International Federation of Clinical Chemistry and Laboratory Medicine) modified
- No interference: bilirubin 70mg/dL, lipemia triglyceride 2200 mg/dL, and hemoglobin 100mg/dL
- Measurement linearity reaches 1400 U/L, with a lower limit of detection of 2.64 U/L
| No. Catalog | R1 | R2 | Kit Size |
| 1 0441 99 10 022 | 5 x 20 mL | 1 X 25 mL | Multi Purpose Kit |
| 1 0441 99 10 027 | 2 x 100 mL | 2 X 25 mL | Multi Purpose Kit |
| 1 0441 99 10 180 | 4 x 20 mL | 4 X 5 mL | TMS50i |
| 1 0441 99 10 190 | 4 x 20 mL | 4 X 5 mL | TMS24i |
| 1 0441 99 10 591 | 4 X 60 mL | 4 X 15 mL | Mindray |
| 1 0441 99 10 914 | 6 X 60 mL | 6 X 15 mL | Hitachi 917 |
| 1 0441 99 10 920 | 4 X 34 mL | 4 X 10 mL | Proline® R-910 |
| 1 0441 99 10 921 | 4 X 21 mL | 4 X 6 mL | Proline® R-910 |
| 1 0441 99 10 951 | 6 X 36 mL | 6 X 9 mL | Advia |
| 1 0441 99 10 965 | 6 X 25 mL | 6 X 6 mL | Other Automated Instrument |
| Women | Men | |||
| Children | [U/L] | [µkat/L] | [U/L] | [µkat/L] |
| 0-1 year | 89-370 | 1.49-6.3 | 89-370 | 1.49-6.3 |
| 1-3 year | 91-334 | 1.52-5.6 | 91-334 | 1.52-5.6 |
| 4-6 year | 97-316 | 1.61-5.3 | 97-316 | 1.61-5.3 |
| 7-11 year | 120-340 | 2-5.7 | 110-316 | 1.83-5.3 |
| 13-17 year | 49-328 | 0.82-5.5 | 75-363 | 1.25-6.1 |
| Elder | 33-98 | 0.55-1.64 | 43-115 | 0.72-1.92 |
- Thomas L. Clinical Laboratory Diagnostics [Internet]. Prof. Lothar Thomas; 2024. Available from: https://www.clinical-laboratory-diagnostics.com/
- Lowe D, Sanvictores T, Zubair M, et al. Alkaline Phosphatase. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-.Available from: https://www.ncbi.nlm.nih.gov/books/NBK459201/
- IFCC primary reference procedures for the measurement of catalytic activity concentrations of enzymes at 37°C. Part 9: Reference procedure for the measurement of catalytic concentration of alkaline phosphatase; Clin Chem Lab Med 2011;49(9).
- Bakker AJ, Mücke M. Gammopathy interference in clinical chemistry assays: mechanisms, detection and prevention. ClinChemLabMed 2007;45(9):1240-1243.
- Guder WG, da Fonseca-Wollheim F, Heil W, Schmitt Y, Töpfer G, Wisser H, Zawta B. Quality of Diagnostic Samples. 3rd edition; 2010. p. 32-3.
- Young DS. Effects of Drugs on Clinical Laboratory Tests. 5th ed. Volume 1 and 2. Washington, DC: The American Association for Clinical Chemistry Press 2000.
- Young DS. Effects on Clinical Laboratory Tests - Drugs Disease, Herbs & Natural Products [Internet]. AACC Press and John Wiley and Sons, Inc; 2020. Available from: https://clinfx.wiley.com/aaccweb/aacc/
- Sonntag O, Scholer A. Drug interference in clinical chemistry: recommendation of drugs and their concentrations to be used in drug interference studies. Ann Clin Biochem. 2001 Jul;38:376-85.
- Liver disease
- Bone Metabolism
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- Email. marketing@proline.co.id
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- Phone. +6221 8984 2722
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- Email. technical.support@prodis.co.id