PROLINE b Cystatin C FS
| Catalogue Number | R1 Reagent Volume | R2 Reagent Volume |
| 17158 99 10 921 | 4 x 20 mL | 4 x 8 mL |
| 17158 99 10 966 | 2 x 13 mL | 2 x 5 mL |
Cystatin C is a non-glycylated basic protein with a low molecular weight of 13 kDa. Cystatin C can act as a cysteine protease inhibitor. Cystatins are produced at a constant rate by all nucleated cells and filtered by the glomerular membrane before being completely absorbed and degraded in the renal tubules. Cystatin C suggests a better marker for detecting decreased glomerular filtration rate (GFR) compared to creatinine, especially for detecting impaired renal function. Cystatin C levels in the blood are different from creatinine, where cystatin C is not determined by sex, muscle mass and age. Determining cystatin C is particularly useful in children, the elderly, diabetics, people with liver cirrhosis, adults receiving kidney transplants, people with cancer and suspected preeclampsia.
Proline Cystatin C FS comes in a liquid format which provides convenience for users as no reconstitution is required which helps reduce the risk of misdiagnosis.
Proline Cystatin C FS reagent is suitable for various third party analyzers such as Abbott, Advia, Cobas, Hitachi, Olympus, Response, TokyoBoeki, and Beckman Coulter. Please contact our technical support at marketing@proline.co.id for further compatibility information on other types of analyzers.
- Ready-to-use liquid reagent (open-system) without reconstitution.
- Excellent linearity and stability performance.
- Available Dedicated Kit.
- Particle enhanced immunoturbidimetric test.
- No interference: bilirubin 60 mg/dL, hemoglobin 1000mg/dL, lipemia to triglycerides 1000mg/dL and RF 600 IU/mL
- Measurement linearity reached 8 mg/dL , with a lower limit of detection of 0.08 mg/dL
| Control for Cystatin C Reagent | Calibrator for Cystatin C Reagent |
| TruLab Cystatin C | TruCal Cystatin C |
Cystatin C is a marker of decreased glomerular filtration rate (GFR), especially to detect moderate renal function impairment. Cystatin C levels were independent of sex, muscle mass, and age.
| Reference Range: | ||
| mg/L | ||
| Adult | ||
| 19 - 49 years | 0.53 – 0.92 | |
| ≥ 50 years | 0.58 – 1.02 | |
| Children | ||
| 4-5 days | 1.22 - 1.68 | |
| < 1 month | 1.37 - 1.89 | |
| 1 - 12 month(s) | 0.73 - 1.17 | |
| > 12 months | 0.60 - 0.84 | |
Each laboratory should check if the reference ranges are transferable to its own patient population and determine own reference ranges if necessary.
- Cystatin C Reagent
- Doos
- Kit insert
- Reagents bottle
- Erland J.E., Randers E., Kristensen J.H. Reference intervals for serum cystatin C and serum creatinine in adults. Clin Chem Lab Med 1998; 36(6):393–397.
- Lamb E., Newman DJ, Price CP Kidney function tests. In: Burtis CA, Ashwood ER, Bruns DE, editors. Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. 4th edition St. Louis Missouri: Elsevier Saunders; 2006; p.823–835.
- Kyhse-Andersen, Schmidt C., Nordin G. et al. Serum cystatin C, determined by a rapid, automated particle-enhanced turbidimetric method, is a better marker than serum creatinine for glomerular filtration rate. ClinChem 1994; 40(10):1921-6.
- Le Bricon T., Leblanc I et al. Evaluation of renal function in intensive care: plasma cystatin C vs. creatinine and derived glomerular filtration rates Clin Chem Lab Med 2005; 43(9):953–957.
- Le Bricon T., Thervet E., Benlakehal M. et al. Changes in Plasma cystatin C after renal transplantation and acute rejection in adults. Clin Chem 1999;45(12):2243-9
- Ustundag Y., Samsar U. et al. Analysis of glomerular filtration rate, serum cystatin C levels, and resistive index values in cirrhosis patients. Clin Chem Lab Med 2007; 45(7):890-94.
- Stabuc B., Vrhovec L. et al. Improved prediction of decreased creatinine clearance by serum cystatin C : Use in cancer patients before and during chemotherapy. Clin Chem 2000; 46(2):193-7.
- Pucci L., Triscornia S., Lucchesi D. et al. Cystatin C and estimates of renal function: searching for a better measure of kidney function in diabetic patients. Clin Chem 2007; 53(3):480-8.
- Strevens H, Wide-Swensson D, Grubb A. Serum cystatin C is abetter marker for preeclampsia than serum creatinine or serum urate. Scand J Clin Lab Invest 2001; 61:575-80.
- Guder WG, Zawta B. et al. The Quality of Diagnostic Samples. 1st ed. Darmstadt: GIT Verlag; 2001; p. 24-5.
- Wiesli P., Schwegler B. et al. Serum cystatin C is sensitive to small changes in thyroid function. Clinica Chimica Acta 2003; 338: 87–90.
- Bökenkamp A, Grabensee A, Stoffel-Wagner B, Hasan C, Henne T, Offner G, Lentze MJ. The ß2- microglobulin/cystatin C ratio: a potential marker of posttransplant lymphoproliferative disease. Clin Nephrol 2001; 58: 417-22.
- Randers E, Krue S, Erlandsen EJ, Danielsen H, Hansen H, Hansen LG. Reference interval for serum cystatin C in children. ClinChem 1999; 45:1856-60.
- Finney H, Newman DJ, Price CP. Adult reference ranges for serum cystatin C, creatinine and predicted creatinine clearance. Ann Clin Biochem 2000; 37:49–59.
- Young DS. Effects of Drugs on Clinical Laboratory Tests. 5th ed. Volume 1 and Washington, DC: The American Association for Clinical Chemistry Press 2000.
- Bakker AJ, Mücke M. Gammopathy interference in clinical chemistry assays: mechanisms, detection and prevention.ClinChemLabMed 2007;45(9):1240–1243.
- Kidney disease
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- Email : marketing@proline.co.id
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- Telp : +62-21-8984-2722
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- Email : technical.support@prodis.co.id