Proline CRP U-hs
| Catalogue Number | R1 Reagent Volume | R2 Reagent Volume |
| 1 7045 99 88 930 | 3 x 20 mL | 3 x 20 mL |
| 1 7045 99 88 920 | 4 x 11 mL | 4 x 11 mL |
Diagnostic reagent for quantitative examination of C-reactive protein (CRP) in serum or plasma in vitro with a photometric system.
CRP U-hs reagent is an additional reagent used together with CRP FS reagent to measure the level of C-reactive protein in samples. High sensitive application is recommended for samples with concentrations below 20 mg/L that require high precision and sensitivity.
C-reactive protein (CRP) is an acute inflammatory protein that plays important roles in inflammatory processes and host responses to infection. CRP is synthesized primarily in liver hepatocytes but also by smooth muscle cells, macrophages, endothelial cells, lymphocytes, and adipocytes. CRP exhibits elevated expression during inflammatory conditions such as rheumatoid arthritis, some cardiovascular diseases, and infection. CRP plasma levels increase from around 1 µg/mL to over 500 µg/mL within 24–72 h of severe tissue damage such as trauma and progressive cancer.
A rise in CRP levels may indicate various health conditions, including cardiovascular diseases, high blood pressure, heart attacks, strokes, and obesity. Since the liver is responsible for CRP production, individuals with liver disorders may experience irregularities in its production. Additionally, a slight increase in CRP levels is common during pregnancy. However, significantly high CRP levels during pregnancy should be closely monitored by a doctor, as they may be linked to complications such as preterm birth or miscarriage. Elevated LDL (bad cholesterol) can also contribute to increased CRP levels. In such cases, a combination of blood vessel abnormalities and high CRP levels raises the likelihood of heart disease, heart attacks, and strokes. Therefore, individuals with high CRP levels should seek medical advice from their doctor.
Any disease that leads to inflammation in the body can cause elevated CRP levels. The most common causes of high CRP include :
- Cardiovascular diseases (e.g., atherosclerosis, heart disease).
- Bacterial infections (e.g., appendicitis, meningitis, cholecystitis).
- Chronic inflammatory diseases (e.g., rheumatoid arthritis).
Particle enhanced immunoturbidimetric test.
- Ready-to-use liquid reagent (open-system) without reconstitution.
- Excellent linearity and stability performance.
- Available in MPK (Multi-Purpose Kit) and dedicated kit.
| Sample type | Serum, heparin plasma or EDTA plasma |
| Measurement range | 0,2 mg/dL - 20 mg/L |
| Analysis wavelength | 340 nm, Hg 334 nm |
| Analysis mode | End point |
| Reagent volume used (analyzer manual) | R1: 250 µL ; R2: 50 µL |
| Sample volume used (analyzer manual) | 15 µL |
| Storage temperature | 2 – 8 °C |
| Open vial stability | 15 months |
| Expiration date | 18 months |
| Control for CRP U-hs Reagent | Calibrator for CRP U-hs Reagent |
| TruLab CRP hs level 1 | TruCal CRP hs 5 levels |
| TruLab CRP hs level 2 |
| Reference Range: | ||
| (mg/L) | ||
| Adult | < 5 | |
| Newborn | < 4.1 | |
| Children | < 2.8 | |
- High sensitivity C-reactive protein reagent
- Doos
- Kit insert
- Reagents bottle
- PROLINE CRP U-hs Kit Insert (17045 01 – Apr 2024/00).
- Sproston, N. R., & Ashworth, J. J. (2018). Role of C-Reactive Protein at Sites of Inflammation and Infection. Frontiers in immunology, 9, 754.
- Melbye, H., Hvidsten, D., Holm, A., Nordbø, S. A., & Brox, J. (2004). The course of C-reactive protein response in untreated upper respiratory tract infection. The British journal of general practice : the journal of the Royal College of General Practitioners, 54(506), 653–658.
- https://www.anadolumedicalcenter.com/health-guide/high-crp-levels-what-it-is-causes-symptoms-and-treatment
- Brochure : INA
- Inflammation
- Atherosclerosis
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