LDH 21 FS (IFCC mod.)

Beranda
Produk Kami
Reagen
Kimia Klinik
LDH 21 FS (IFCC mod.)

Juli 27, 2024

LDH 21 FS (IFCC mod.)

Product No: 1 4251

Deskripsi

Lactate dehydrogenase (LDH) is an enzyme, consisting of five different isoenzymes which catalyze the interconversion of L-lactate and pyruvate. LDH is present in the cytoplasm of all human tissues with higher concentrations in liver, heart and skeletal muscle and lower values in erythrocytes, pancreas, kidney and stomach. Increased LDH activities are found in a variety of pathological conditions such as myocardial infarction, cancer, diseases of liver, blood or muscle. However, because of the lack of organ specificity, determination of its isoenzymes or other enzymes such as alkaline phosphatase or ALAT/ASAT is necessary for differential diagnosis. [1,2]

Fitur

Reagen siap pakai.

Proline LDH 21 FS (IFCC mod.) comes in a liquid format which provides convenience for users as no reconstitution is required which helps reduce the risk of misdiagnosis.

Reagen dengan sistem terbuka, kompatibel untuk beragam instrumen.

Proline LDH 21 FS (IFCC mod.) reagent is suitable for various third party analyzers such as Abbott, Advia, Cobas, Hitachi, Olympus, Response, TokyoBoeki, and Beckman Coulter. Please contact our technical support at marketing@proline.co.id for further compatibility information on other types of analyzers.

Spesifikasi

Optimized UV-test according to IFCC (International Federation of Clinical Chemistry and Laboratory Medicine)
No interfering substances: Ascorbic acid 60 mg/dL, Bilirubin (conjugated) 60 mg/dL, Lipemia (triglycerides) 2000 mg/dL, Sulfapyridine 30 mg/dL, Sulfasalazine 30 mg/dL
Measurement linearity reaches 1500 U/L, with a lower limit of detection of 15 U/L

Kalibrator

TruCal U

Kontrol

Varian Kit

No. Katalog	R1	R2	Jenis Kit
1 4251 99 10 021	5 X 20 mL	1 X 25 mL	Kit Serba Guna (MPK)
1 4251 99 10 920	4 X 34 mL	4 X 10 mL	Proline® R-910

Rentang Referensi

	Female		Male

	U/L	µkat/L	U/L	µkat/L
Dewasa	< 247	< 4.12	< 248	< 4.14
Anak-anak
1 – 30 day(s)	145 – 765	2.42 – 12.8	125 – 735	2.09 – 12.3
31 – 365 hari	190 – 420	3.17 – 7.01	170 – 450	2.84 – 7.52
1 – 3 year(s)	165 – 395	2.76 – 6.60	155 – 345	2.59 – 5.76
4 – 6 tahun	135 – 345	2.25 – 5.76	155 – 345	2.59 – 5.76
7 – 9 tahun	140 – 280	2.34 – 4.68	145 – 300	2.42 – 5.01
10 – 12 tahun	120 – 260	2.00 – 4.34	120 – 325	2.00 – 5.43
13 – 15 tahun	100 – 275	1.67 – 4.59	120 – 290	2.00 – 4.84
16 – 18 tahun	105 – 230	1.75 – 3.84	105 – 235	1.75 – 3.92

Setiap laboratorium harus memeriksa apakah referensi rentang dapat dikalkulasikan untuk populasi pasiennya dan menentukan referensi rentang sendiri jika diperlukan.

Referensi

1. Thomas L. Clinical laboratory diagnostics. 1st ed. Frankfurt: TH-Books Verlagsgesellschaft; 1998. p. 89-94.
Moss DW, Henderson AR. Clinical enzymology In: Burtis CA, Ashwood ER, editors. Tietz Textbook of Clinical Chemistry. 3rd ed. Philadelphia: W.B Saunders Company;1999. 617-721.
Bakker AJ, Mücke M. Gammopathy interference in clinical chemistry assays: Mechanisms, detection and prevention. Clin Chem Lab med 2007; 45(9): 1240-1243.
Guder WG, Zawta B et al. The Quality of Diagnostic Samples. 1st ed. Darmstadt: GIT Verlag; 2001; p. 36-7.
Young DS. Effects of Drugs on Clinical Laboratory Tests. 5th ed. Volume 1 and 2. Washington, DC: The American Association for Clinical Chemistry Press 2000.
Young DS. Effects on Clinical Laboratory Tests - Drugs Disease, Herbs & Natural Products, https://clinfx.wiley.com/aaccweb/aacc/, accessed in March 2021. Published by AACC Press and John Wiley and Sons, Inc.
Schumann G, Bonora R, Ceriotti F, Férard G et al. IFCC primary reference procedure for the measurement of catalytic activity concentrations of enzymes at 37°C. Part 3: Reference procedure for the measurement of catalytic concentration of lactate dehydrogenase. Clin Chem Lab Med 2002;40:643-48.
Soldin JS, Hicks JM. Pedia