Proline Calcium P FS
| Catalogue Number | R1 Reagent Volume | R2 Reagent Volume |
| 1 1181 9988920 | 4 x 38 mL | 4 x 11 mL |
| 1 1181 9988021 | 4 x 20 mL | 1 x 20 mL |
| 1 1181 9988026 | 5 x 80 mL | 1 x 100 mL |
Diagnostic reagent for the quantitative examination of calcium in human serum or heparin plasma in vitro using a photometric system.
Calcium is an essential molecule in the body, involved in numerous biochemical processes. This mineral is crucial for heart function, kidney function, structural integrity of bones, muscle contraction, and acts as an enzymatic signal in biochemical pathways.
Osteoporosis is an assessment of bone density and is associated with an increased risk of fractures due to bone fragility. There are two types of osteoporosis: Primary osteoporosis, which occurs due to aging (senile osteoporosis) or after menopause (postmenopausal osteoporosis). Secondary osteoporosis, which results from various disorders and medication side effects. The secondary causes of bone loss—including drug therapy side effects, endocrine disorders, eating disorders, kidney disease, and cancer—are often undiagnosed in osteoporosis patients.
Calcium is a major structural component of bone minerals, ensuring skeletal health. Insufficient calcium intake can lead to osteoporosis and an imbalance between bone resorption (osteoclast activity) and new bone formation (osteoblast activity). Calcium is obtained through diet or supplements and is excreted through urine.
A condition where the body absorbs more calcium than needed is called hypercalcemia, which is one of the causes of kidney stones. The management of chronic kidney disease-mineral and bone disorder (CKD-MBD) involves regulating serum phosphorus and calcium levels in the body. Patients undergoing hemodialysis with impaired kidney function must regularly monitor their calcium and phosphate levels.
Parathyroid Hormone (PTH): Released in response to decreased serum calcium levels, increasing calcium absorption in the kidneys.
1,25-Dihydroxyvitamin D-3 (Vitamin D3): The active form of vitamin D that regulates calcium and phosphate metabolism.
Calcitonin: Lowers blood calcium levels and helps maintain bone health.
Photometric with Phosphonazo III.
- Ready-to-use liquid reagent (open-system) without reconstitution
- Excellent linearity and stability performance
- Available in MPK (Multi-Purpose Kit) and dedicated kit
- Compatible with >65 brands of manual and automated clinical chemistry analyzers
| Sample type | Serum, plasma heparin or urine. |
| Measurement range | 0.35 mg/dL - 16 mg/dL |
| Analysis wavelength | 660 nm or 700/800 nm bi-chromatic |
| Analysis mode | End-Point |
| Reagent volume used (analyzer manual) | 250 µL - 1000 µL |
| Sample volume used (analyzer manual) | 10 µL |
| Storage temperature | 2 – 8 °C |
| Open vial stability | 18 months |
| Expiration date | 24 months |
| Reference Range: | ||
| (mg/dL) | (mmol/L) | |
| Serum/Plasma | 8.6 – 10.3 | 2.15 – 2.57 |
| Urine | ||
| Woman | < 250 mg/24 hours | 6.24 mmol/24 hours |
| Man | < 300 mg/24 hours | 7.49 mmol/24 hours |
- Calcium Reagent
- Doos
- Kit insert
- Reagents bottle
- PROLINE. PROLINE Calcium P FS Kit Insert [Update: 11181 01 – Feb 2024/00)]
- Drake TM, Gupta V. Calcium. [Updated 2024 Jan 8]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK557683/
- Voulgaridou, Gavriela et al. “Vitamin D and Calcium in Osteoporosis, and the Role of Bone Turnover Markers: A Narrative Review of Recent Data from RCTs.” Diseases (Basel, Switzerland) vol. 11,1 29. 8 Feb. 2023, doi:10.3390/diseases11010029
- Inaguma, D., Koide, S., Takahashi, K. et al. Relationship between serum calcium level at dialysis initiation and subsequent prognosis. Ren Replace Ther 3, 2 (2017). https://doi.org/10.1186/s41100-016-0087-2
- Yu E, Sharma S. Physiology, Calcium. [Updated 2023 Aug 14]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK482128/
- Brochure : INA
- Bone Metabolism
- Liver Disease
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