PROLINE Creatinine PAP FS
| Catalogue Number | R1 Reagent Volume | R2 Reagent Volume |
| 11759 99 10 890 | 4 x 2,5 mL | 2 x 2,5 mL |
| 11759 99 88 022 | 4 x 20 mL | 2 x 20 mL |
| 11759 99 88 181 | 4 x 36 mL | 4 x 18 mL |
| 11759 99 88 191 | 4 x 36 mL | 4 x 18 mL |
| 11759 99 88 890 | 1 x 10 mL | 2 x 2,5 mL |
| 11759 99 88 920 | 4 x 34 mL | 4 x 19 mL |
| 11759 99 88 921 | 4 x 21 mL | 4 x 11 mL |
Creatinine is a waste product excreted by the kidneys mainly by glomerular filtration. The concentration of creatinine in the plasma of a healthy individual is fairly constant, independent of water intake, exercise, and rate of urine production. Therefore, increased plasma creatinine values always indicate decreased excretion, i.e. impaired kidney function. The creatinine clearance enables a quite good estimation of the glomerular filtration rate (GFR) which allows better detection of kidney diseases and monitoring of renal function. For this purpose, creatinine is measured simultaneously in serum and urine collected over a defined time period.
| Increased in | Decreased in |
| Impaired kidney function. Serum creatinine is a more specific indicator of kidney disease than serum urea. |
Decreased muscle mass (eg muscular dystrophy, myasthenia gravis) |
| Urinary tract obstruction | |
| Diabetes | |
| Rhabdomyolysis | |
| Acromegaly | |
| Nephritis |
- Enzymatic colorimetric test
- No interference: ascorbic acid 25 mg/dL, bilirubin up to 20 mg/dL, and hemoglobin up to 400 mg/dL, creatine up to 40 mg/dL and lipemia 1500 mg/dL triglyceride.
- Measurement of linearity : reaches 160 mg/dL, with a detection limit of 0.03 mg/dL
| Control for Creatinine PAP Reagent | Calibrator for Creatinine PAP Reagent |
| TruLab N | TruCal U |
| TruLab P | Creatinine Standard FS |
| Reference Range: | ||
| mg/dL | µmol/L | |
| Serum / Plasma | ||
| Adult | ||
| Women | 0.51 – 0.95 | 45 – 84 |
| Men | 0.67 – 1.17 | 59 – 104 |
| Children | ||
| 0 – 7 day | 0.6 – 1.1 | 53 – 97 |
| 1 week – 1 month | 0.3 – 0.7 | 27 – 62 |
| 1 – 12 month | 0.2 – 0.4 | 18 – 35 |
| 1 – 18 year | 0.2 – 0.7 | 18 – 62 |
| mg/dL | mmol/L | |
| Morning first urine | ||
| Women | 29 – 226 | 2.55 – 20.0 |
| Men | 40 – 278 | 3.54 – 24.6 |
| Urine 24 hours | ||
| Women | 720 – 1510 | 6 – 13 |
| Men | 980 – 2200 | 9 – 19 |
| Creatinine clearance | 66.3 – 143 mL/min/1.73 m² |
| Albumine/creatinine ratio (morning urine) | < 30 mg/g Creatinine |
Each laboratory should check if the reference ranges are transferable to its own patient population and determine own reference ranges if necessary
- Creatinine Reagent
- Doos
- Kit insert
- Reagents bottle
- Newman DJ, Price CP. Renal function and nitrogen metabolites. In: Burtis CA, Ashwood ER,editors. Tietz Textbook of Clinical Chemistry. 3rd ed. Philadelphia: W.B Saunders Company;1999. p. 1204-1270.
- Thomas L. Clinical Laboratory Diagnostics. 1st ed. Frankfurt: TH-Books Verlagsgesellschaft; 1998. p. 366-74.
- Mazzachi BC, Peake MJ, Ehrhardt V. Reference Range and Method Comparison Studies forEnzymatic and Jaffé Creatine Assays in Plasma and Serum and Early Morning Urine. Clin.Lab. 2000; 46: 53-55.
- Guder WG, Zawta B. Recommendations of the Working group on Preanalytical Quality of the German Society for Clinical Chemistry and the German Society for Laboratory Medicine: The Quality of Diagnostic Samples. 1st ed Darmstadt: GIT Verlag 2001; p. 24-5,50-1
- Levey AS, Coresh J, Greene T, Marsh J et al: Expressing the Modification of Diet in Renal Disease Study Equation for Estimating Glomerular Filtration Rate with Standardized Serum Creatinine Values. Clin Chem 2007; 53 (4): 766-72.
- Junge W, Wilke B, Halabi A, Klein G. Determination of reference intervals for erum creatinine, creatinine excretion and creatinine clearance with an enzymatic and a modified Jaffé method. Clin Chim Acta 2004; 344: 137-148
- Soldin SJ, HicksJM. Pediatric reference range. Washinton : AACC Press, 1995 :50.
- Young DS. Effects of Drugs on Clinical laboratory Tests. 5th ed. Volume 1 and 2. Washington, DC: The American Association for Clinical Chemistry Press 2000.
- Bakker AJ, Mücke M. Gammopathyinterference in clinical chemistry assays: mechanisms, detection and prevention. ClinChemLabMed 2007;45(9):1240-1243.
- Kidney Disease
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