Glucose Hexokinase FS

November 15, 2024

Glucose Hexokinase FS

Product Number: 1 2511

Description

Measurement of glucose concentration in serum or plasma is mainly used in the diagnosis and monitoring of the therapy of diabetes mellitus.

Other applications are for the detection of neonatal hypoglycemia, pancreatic islet cell carcinoma and the evaluation of carbohydrate metabolism in various diseases.

Increased in

Diabetes mellitus
Advanced age – onset (Adult)
Age of growth – onset (Teenager)
Pancreatitis
Endocrine disorders, eg. acromegaly, Cushing's syndrome, thyrotoxicosis, pheochromohyperaldosteronism
Drugs, eg. steroids, thiazides, oral contraceptives
Chronic kidney failure
Emphasize
I.V. glucose infusion
Postprandial

Decreased in

Insulinoma
Adrenal cortex insufficiency
Hypopituitarism
Extra – pancreatic neoplasm
Severe liver disease
Alcohol consumption
Drugs, eg. sulfonylureas, salicylates, phenformin, insulin, etc.

Features

Ready to use reagent.

Proline Glucose Hexokinase FS comes in a liquid format which provides convenience for users as no reconstitution is required which helps reduce the risk of misdiagnosis.

Open system reagent, compatible with a wide range of instruments.

Proline Glucose Hexokinase FS reagent is suitable for various third-party analyzers such as Abbott, Advia, Cobas, Hitachi, Olympus, Response, TokyoBoeki, and Beckman Coulter. Please contact our technical support at marketing@proline.co.id for further compatibility information on other types of analyzers.

Specification

Enzymatic UV test using hexokinase
No interference: ascorbic acid 30mg/dL, bilirubin 60mg/dL, hemoglobin 500mg/dL and lipemia up to 1800mg/dL triglycerides
Measurement linearity reached 500 mg/dL, with a lower limit of detection of 2 mg/dL

Calibrator

TruCal U

Control

kit Lines

No. Catalog	R1	R2	Kit Size
1 2511 99 10 022	5 X 20 mL	1 X 25 mL	Multi Purpose Kit
1 2511 99 10 025	3 X 80 mL	1 X 60 mL	Multi Purpose Kit
1 2511 99 10 027	2 X 100 mL	2 X 25 mL	Multi Purpose Kit
1 2511 99 10 029	3 X 200 mL	1 X 150 mL	Multi Purpose Kit
1 2511 99 10 181	4 X 36 mL	4 X 9 mL	TMS50i
1 2511 99 10 191	4 X 36 mL	4 X 9 mL	TMS24i
1 2511 99 10 591	4 X 60 mL	4 X 15 mL	Mindray
1 2511 99 10 914	6 X 60 mL	6 X 15 mL	Hitachi 917
1 2511 99 10 920	4 X 38 mL	4 X 11 mL	Proline® R-910
1 2511 99 10 951	6 X 36 mL	6 X 9 mL	Advia
1 2511 99 10 965	6 X 25 mL	6 X 6 mL	Other Automated Instrument

Reference Range

Adult (Fasting)
Plasma venous	70 – 115 mg/dL	3.9 – 6.4 mmol/L
Blood	70 – 100 mg/dL	3.9 – 5.6 mmol/L
Newborn
Umbilical cord blood	63 – 158 mg/dL	3.5 – 8.8 mmol/L
1 hour	36 – 99 mg/dL	2.0 – 5.5 mmol/L
2 hours	36 – 89 mg/dL	2.2 – 4.9 mmol/L
5 – 14 hours	34 – 77 mg/dL	1.9 – 4.3 mmol/L
10 – 28 hours	46 – 81 mg/dL	2.6 – 4.5 mmol/L
44 – 52 jam	48 – 79 mg/dL	2.7 – 4.4 mmol/L

Children and teenager (fasting)
1 – 6 year(s)	74 – 127 mg/dL	4.1 – 7.0 mmol/L
7 – 19 years	70 – 106 mg/dL	3.9 – 5.9 mmol/L

Each laboratory should check if the reference ranges are transferable to its own patient population and determine its own reference ranges if necessary

References

Thomas L. Clinical Laboratory Diagnostics. 1 ed. Frankfurt: TH-Books Verlagsgesellschaft; 1998. p. 131-7."
Sacks DB. Carbohydrates. In: Burtis CA, Ashwood ER, editors. Tietz Textbook rd of Clinical Chemistry. 3 ed. Philadelphia: W.B Saunders Company; 1999. p. 750-808.
Guder WG, Zawta B et al. The Quality of Diagnostic Samples. 1 ed. Darmstadt: GIT Verlag; 2001; p. 30-1.
Sacks DB, Bruns DE, Goldstein DE, Mac Laren NK, Mc Donald JM, Parrott M. Guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus. Clin Chem 2002; 48: 436-72.
Young DS. Effects of Drugs on Clinical Laboratory Tests. 5th ed. Volume 1 and 2. Washington, DC: The American Association for Clinical Chemistry Press 2000.on. ClinChemLabMed 2007;45(9):1240-1243.
Bakker AJ, Mücke M. Gammopathy interference in clinical chemistry assays: mechanisms, detection and prevention. ClinChemLabMed 2007;45(9):1240-1243.