April 19, 2025

Alkaline Phosphatase FS (IFCC mod. 37°C)

PROLINE Alkaline Phosphatase FS IFCC 37°C

Product Description

Alkaline phosphatase (AP) is a cell membrane-bound enzyme expressed by all tissues. AP, with its cofactors zinc and magnesium, catalyzes the hydrolysis of organic phosphate esters in the extracellular space. AP is found in the blood in various different forms, mainly from bones and liver, but also from other tissues such as kidneys, placenta, testes, thymus, lungs and tumors.

Increased AP activity can appear physiologically, for example during the second trimester of pregnancy and in childhood during growth. Pathological conditions that cause increased AP activity are hepatobiliary diseases, skeletal system diseases, malignant tumors, and systemic diseases without primary liver and bone involvement. Decreased AP activity in serum is very rare and, if present, is found in hereditary hypophosphatemia, Wilson's disease, and corticoid-induced osteoporosis.

Alkaline Phosphatase levels in the body increase during:	Alkaline Phosphatase levels in the body decrease during:
Intrahepatic cholestasis, (example: liver infiltrate by carcinoma, leukemia, tuberculosis, sarcoidosis, amyloidosis, fibrosis (cirrhosis))	Hypophosphatasemia: a relatively rare inherited disorder that is asymptomatic or may be associated with arthritis of weight-bearing
Extrahepatic cholestasis, (examples: bile duct stones, neoplasms, atresia)	Hypothyroidism
Osteoblastic diseases, (e.g. malignancy, secondary hyperparathyroidism, Paget's disease)	Scurvy
Tumor	Severe anemia
Pregnancy

Features

Ready to use reagent.

Proline Alkaline Phosphatase FS (IFCC mod. 37°C) comes in a liquid format which provides convenience for users as no reconstitution is required which helps reduce the risk of misdiagnosis.

Open system reagent, compatible with a wide range of instruments.

Proline Alkaline Phosphatase FS (IFCC mod. 37°C) reagent is suitable for various third party analyzers such as Abbott, Advia, Cobas, Hitachi, Olympus, Response, TokyoBoeki, and Beckman Coulter. Please contact our technical support at marketing@proline.co.id for further compatibility information on other types of analyzers.

Specifications

The optimized UV test according to the IFCC (International Federation of Clinical Chemistry and Laboratory Medicine.
No interference: bilirubin 70mg/dL, lipemia triglyceride 2200 mg/dL, and hemoglobin 100mg/dL
Measurement linearity reaches 1400 U/L, with a lower limit of detection of 2.64 U/L

Control dan Calibrator

Control for Alkaline Reagent	Calibrator for Alkaline Reagent
TruLab N	TruCal U
TruLab P

Reference Range

	Wanita		Pria
Anak-anak	[U/L]	[µkat/L]	[U/L]	[µkat/L]
0-1 year	89-370	1.49-6.3	89-370	1.49-6.3
1-3 year	91-334	1.52-5.6	91-334	1.52-5.6
4-6 year	97-316	1.61-5.3	97-316	1.61-5.3
7-11 year	120-340	2-5.7	110-316	1.83-5.3
13-17 tahun	49-328	0.82-5.5	75-363	1.25-6.1

Dewasa	33-98	0.55-1.64	43-115	0.72-1.92