Calcium P FS

Product Number: 1 1811


Calcium plays an essential role in many cell functions: intracellular in muscle contraction and glycogen metabolism, extracellular in bone mineralization, in blood coagulation and in transmission of nerve impulses. Calcium in plasma exists in three forms: free, bound to proteins or bound to anions such as phosphate, citrate and bicarbonate in a complex reaction. Decreased total calcium levels can be associated with diseases of the bone apparatus (especially osteoporosis), kidney diseases (especially under dialysis), defective intestinal absorption and hypoparathyroidism. Increased total calcium can be measured in hyperparathyroidism, malignant diseases with metastases and sarcoidosis. Calcium measurements also help in monitoring of calcium supplementation mainly in the prevention of osteoporosis.

Increased in

  • Hyperparathyroidism
  • Myeloma
  • Metastatic carcinoma
  • Sarcoidosis
  • Thiazide therapy
  • Thyrotoxicosis

Decreased in

  • Decreased muscle mass (eg muscular dystrophy, myasthenia gravis)


Ready to use reagent.

Proline Calcium P FS comes in a liquid format which provides convenience for users as no reconstitution is required which helps reduce the risk of misdiagnosis.

Open system reagent, compatible with a wide range of instruments.

Proline Calcium P FS reagent is suitable for various third party analyzers such as Abbott, Advia, Cobas, Hitachi, Olympus, Response, TokyoBoeki, and Beckman Coulter. Please contact our technical support at for further compatibility information on other types of analyzers.


  • Photometric endpoint determination with Phosphonazo III
  • No interference: ascorbic acid 30 mg/dL, bilirubin 60 mg/dL, hemoglobin 1000mg/dL, lipemia to triglycerides 2000mg/dL, and magnesium 20 mg/dL
  • Measurement linearity reached 25 mg/dL (6.24 mmol/L), with a lower limit of detection 0.2 mg/dL



Kit Lines

No. Catalog R1 R2 Kit Size
1 1811 99 10 021 4 X 20 mL 1 X 20 mL Multi Purpose Kit
1 1811 99 10 026 5 X 80 mL 1 X 100 mL Multi Purpose Kit
1 1811 99 10 920 4 X 38 mL 4 X 11 mL Proline® R-910

Reference Range

Adults 8.6 – 10.3 mg/dL 2.15 – 2.57 mmol/L
New born or premie 6.2-11.0 mg/dL 1.55-2.75 mmol/L
Children < 10 days 7.6-10.4 mg/dL 1.90-2.60 mmol/L
Children 11 days - 2 years 9.0-11.0 mg/dL 2.25-2.75 mmol/L
Children 3-12 years 8.8-10.8 mg/dL 2.20-2.70 mmol/L
Children 13-18 years 8.4-10.2 mg/dL 2.10-2.55 mmol/L


Women < 250 mg/24h 6.24 mmoL/24h
Men < 300 mg/24h 7.49 mmoL/24h

Each laboratory should check if the reference ranges are transferable to its own patient population and determine its own reference ranges if necessary.


  1. Thomas L. Clinical Laboratory Diagnostics. 1st ed. Frankfurt: TH-Books Verlagsgesellschaft; 1998. p. 231-241.
  2. Endres DB, Rude RK. Mineral and bone metabolism. In: Burtis CA, Ashwood ER, editors. Tietz Textbook of Clinical Chemistry. 3rd ed. Philadelphia: W.B Saunders Company; 1999. p. 1395-1406.
  3. Guder WG, Zawta B et al. The Quality of Diagnostic Samples. 1st ed. Darmstadt:
  4. GIT Verlag; 2001. p. 20-1 and p. 50-1.
    Young DS. Effects of Drugs on Clinical Laboratory Tests. 5th ed. Volume 1 and 2. Washington, DC: The American Association for Clinical Chemistry Press 2000.
  5. Bakker AJ, Mücke M. Gammopathy interference in clinical chemistry assays: mechanisms, detection and prevention. ClinChemLabMed 2007;45(9):1240- 1243.


  • Bone Metabolism
  • Liver Disease

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