Cholinesterase FS
Cholinesterase (ChE) is a group of enzymes that are broken down into choline and thiocholine esters. The names Serum Cholinesterase and Pseucholinesterase are also commonly used. ChE measurements in serum and plasma are synthesized in the liver and are prescribed in the diagnosis of liver disease, nephrotic syndrome and intestinal diseases with protein loss (exudative enterudate).
Very low values may indicate pesticide poisoning. ChE measurement is also part of preoperative diagnostics because ChE is required for the inactivation of muscle relaxants that are often used during surgery.
- Nefrotic Syndrome
- Fatty Liver
- Exudative Enteropathy
- Pesticide poisoning
- Liver disease
- Atypical ChE form
Proline Cholinesterase FS comes in a liquid format which provides convenience for users as no reconstitution is required which helps reduce the risk of misdiagnosis.
Proline Cholinesterase FS reagent is suitable for various third party analyzers such as Abbott, Advia, Cobas, Hitachi, Olympus, Response, TokyoBoeki, and Beckman Coulter. Please contact our technical support at marketing@proline.co.id for further compatibility information on other types of analyzers.
- Kinetic photometric test, the optimal method according to the recommendations of the German Society of Clinical Chemistry (DGKC).
- No interference: ascorbic acid 30 mg/dL, bilirubin 45 mg/dL, hemoglobin 1000mg/dL, lipemia to triglycerides 1400mg/dL
- Measurement linearity reaches 20000 U/L with a lower limit of detection 50U/L
| No. Catalog | R1 | R2 | Kit Size |
| 1 1401 99 10 021 | 5 X 20 mL | 1 X 25 mL | Multi Purpose Kit |
| 1 1401 99 10 921 | 4 X 6 mL | 4 X 9 mL | Proline® R-910 |
| 1 1401 99 10 930 | 4 X 20 mL | 2 X 10 mL | Hitachi 704/717/902/911/912/917 |
| 1 1401 99 10 962 | 6 X 33 mL | 6 X 11 mL | Other Atutomated Instrument |
Cholinesterase (ChE) is an enzyme that allows the diagnosis of liver disease, nephrotic syndrome and intestinal disease.
| Adults | |
| Women | 3.93 – 10.8 kU/L (65.5– 180 µkat/L) |
| Men | 4.62 – 11.5 kU/L (77 – 192 µkat/L) |
Each laboratory should check if the reference ranges are transferable to its own patient population and determine own reference ranges if necessary.
- Recommendations of the German Society for Clinical Chemistry. Standardization of methods for the estimation of enzyme activities in biological fluids: Standard method for the determination of Cholinesterase activity. J Clin Chem Clin Biochem 1992;30:163-70.
- Thomas L, Clinical laboratory diagnostics. 1st ed Frankfurt: THBooksVerlagsgesellschaft;1998. p.65–71.
- Hallbach J, Klinische Chemie für den Einstieg. 1st ed Stuttgart: Thieme;2001. p.143-4.
- Young DS. Effects of Drugs on Clinical Laboratory Tests. 5th ed. Volume 1 and 2. Washington, DC: The American Association for Clinical Chemistry Press 2000.
- Bakker AJ, Mücke M. Gammopathy interference in clinical chemistry assays: mechanisms, detection and prevention. ClinChemLabMed 2007;45(9):1240–1243.
- Liver disease
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- Phone. +6221 8984 2722
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- Email. marketing@proline.co.id
Contact our Technical Assistance team for further assistance with product specifications, services and other technical documents.
- Phone. +6221 8984 2722
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- Email. technical.support@prodis.co.id