Cholinesterase FS

Product number : 1 1401


Cholinesterase (ChE) is a group of enzymes that are broken down into choline and thiocholine esters. The names Serum Cholinesterase and Pseucholinesterase are also commonly used. ChE measurements in serum and plasma are synthesized in the liver and are prescribed in the diagnosis of liver disease, nephrotic syndrome and intestinal diseases with protein loss (exudative enterudate).

Very low values ​​may indicate pesticide poisoning. ChE measurement is also part of preoperative diagnostics because ChE is required for the inactivation of muscle relaxants that are often used during surgery.

Increased in

  • Nefrotic Syndrome
  • Fatty Liver
  • Exudative Enteropathy

Decreased in

  • Pesticide poisoning
  • Liver disease
  • Atypical ChE form


Ready to use reagent.

Proline Cholinesterase FS comes in a liquid format which provides convenience for users as no reconstitution is required which helps reduce the risk of misdiagnosis.

Open system reagent, compatible with a wide range of instruments.

Proline Cholinesterase FS reagent is suitable for various third party analyzers such as Abbott, Advia, Cobas, Hitachi, Olympus, Response, TokyoBoeki, and Beckman Coulter. Please contact our technical support at for further compatibility information on other types of analyzers.


  • Kinetic photometric test, the optimal method according to the recommendations of the German Society of Clinical Chemistry (DGKC).
  • No interference: ascorbic acid 30 mg/dL, bilirubin 45 mg/dL, hemoglobin 1000mg/dL, lipemia to triglycerides 1400mg/dL
  • Measurement linearity reaches 20000 U/L with a lower limit of detection 50U/L



Kit Lines

No. Catalog R1 R2 Kit Size
1 1401 99 10 021  5 X 20 mL 1 X 25 mL Multi Purpose Kit
1 1401 99 10 921 4 X 6 mL 4 X 9 mL Proline® R-910
1 1401 99 10 930 4 X 20 mL 2 X 10 mL Hitachi 704/717/902/911/912/917
1 1401 99 10 962 6 X 33 mL 6 X 11 mL Other Atutomated Instrument

Reference Range

Cholinesterase (ChE) is an enzyme that allows the diagnosis of liver disease, nephrotic syndrome and intestinal disease.

 Women 3.93 – 10.8 kU/L (65.5– 180 µkat/L)
 Men 4.62 – 11.5 kU/L (77 – 192 µkat/L)

Each laboratory should check if the reference ranges are transferable to its own patient population and determine own reference ranges if necessary.


  1. Recommendations of the German Society for Clinical Chemistry. Standardization of methods for the estimation of enzyme activities in biological fluids: Standard method for the determination of Cholinesterase activity. J Clin Chem Clin Biochem 1992;30:163-70.
  2. Thomas L,  Clinical  laboratory  diagnostics.  1st  ed  Frankfurt:  THBooksVerlagsgesellschaft;1998. p.65–71.
  3. Hallbach J, Klinische Chemie für den Einstieg. 1st ed Stuttgart: Thieme;2001. p.143-4.
  4. Young DS. Effects of Drugs on Clinical Laboratory Tests. 5th ed. Volume 1 and 2. Washington, DC: The American Association for Clinical Chemistry Press 2000.
  5. Bakker AJ, Mücke M. Gammopathy interference in clinical chemistry assays: mechanisms, detection and prevention. ClinChemLabMed 2007;45(9):1240–1243.


  • Liver disease

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