Creatinine PAP FS

April 19, 2024

Creatinine PAP FS

Product Number: 1 1759

Description

Creatinine is a waste product excreted by the kidneys mainly by glomerular filtration. The concentration of creatinine in the plasma of a healthy individual is fairly constant, independent of water intake, exercise, and rate of urine production. Therefore, increased plasma creatinine values always indicate decreased excretion, i.e. impaired kidney function. The creatinine clearance enables a quite good estimation of the glomerular filtration rate (GFR) which allows better detection of kidney diseases and monitoring of renal function. For this purpose, creatinine is measured simultaneously in serum and urine collected over a defined time period.

Increased in

Impaired kidney function. Serum creatinine is a more specific indicator of kidney disease than serum urea.
Urinary tract obstruction
Diabetes
Rhabdomyolysis
Acromegaly
Nephritis

Decreased in

Decreased muscle mass (eg muscular dystrophy, myasthenia gravis)

Features

Ready to use reagent.

Proline Creatinine PAP FS comes in a liquid format which provides convenience for users as no reconstitution is required which helps reduce the risk of misdiagnosis.

Open system reagent, compatible with a wide range of instruments.

Proline Creatinine PAP FS reagent is suitable for various third party analyzers such as Abbott, Advia, Cobas, Hitachi, Olympus, Response, TokyoBoeki, and Beckman Coulter. Please contact our technical support at marketing@proline.co.id for further compatibility information on other types of analyzers.

Specification

Enzymatic colorimetric test
No interference: ascorbic acid 25 mg/dL, bilirubin up to 20 mg/dL, and hemoglobin up to 400 mg/dL, creatine up to 40 mg/dL and lipemia 1500 mg/dL triglyceride.

Evaluation on Proline R-910

Measurement of linearity : reaches 160 mg/dL, with a detection limit of 0.03 mg/dL

Calibrator

Control

Kit Lines

No. Catalog	R1	R2	Kit Size
1 1759 99 10 022	5 X 20 mL	1 X 25 mL	Multi Purpose Kit
1 1759 99 10 181	4 X 36 mL	4 X 9 mL	TMS50i
1 1759 99 10 191	4 X 36 mL	4 X 9 mL	TMS24i
1 1759 99 10 591	4 X 60 mL	4 X 15 mL	Mindray
1 1759 99 10 914	6 X 60 mL	6 X 15 mL	Hitachi 917
1 1759 99 10 920	4 X 38 mL	4 X 11 mL	Proline® R-910
1 1759 99 10 921	4 X 21 mL	4 X 6 mL	Proline® R-910
1 1759 99 10 951	6 X 36 mL	6 X 9 mL	Advia
1 1759 99 10 965	6 X 25 mL	6 X 6 mL	Other Automated Instrument

Reference Range

Serum / Plasma
Adults
Women	0.51 – 0.95 mg/dL	45 – 84 µmol/L
Men	0.67 – 1.17 mg/dL	59 – 104 µmol/L
Children
0 – 7 day	0.6 – 1.1 mg/dL	53 – 97 µmol/L
1 week – 1 month	0.3 – 0.7 mg/dL	27 – 62 µmol/L
1 – 12 month	0.2 – 0.4 mg/dL	18 – 35 µmol/L
1 – 18 year	0.2 – 0.7 mg/dL	18 – 62 µmol/L

Morning first urine
Women	29 – 226 mg/dL	2.55 – 20.0 mmol/L
Men	40 – 278 mg/dL	3.54 – 24.6 mmol/L

Urine 24 hour
Women	720 – 1510 mg/d	6 – 13 mmol/d
Men	980 – 2200 mg/d	9 – 19 mmol/d

Creatinine clearance
		66.3 – 143 mL/min/1.73 m²

Albumine/creatinine ratio (morning urine)
	< 30 mg/g Creatinine

Each laboratory should check if the reference ranges are transferable to its own patient population and determine own reference ranges if necessary

Reference

Newman DJ, Price CP. Renal function and nitrogen metabolites. In: Burtis CA, Ashwood ER,editors. Tietz Textbook of Clinical Chemistry. 3rd ed. Philadelphia: W.B Saunders Company;1999. p. 1204-1270.
Thomas L. Clinical Laboratory Diagnostics. 1st ed. Frankfurt: TH-Books Verlagsgesellschaft; 1998. p. 366-74.
Mazzachi BC, Peake MJ, Ehrhardt V. Reference Range and Method Comparison Studies forEnzymatic and Jaffé Creatine Assays in Plasma and Serum and Early Morning Urine. Clin.Lab. 2000; 46: 53-55.
Guder WG, Zawta B. Recommendations of the Working group on Preanalytical Quality of the German Society for Clinical Chemistry and the German Society for Laboratory Medicine: The Quality of Diagnostic Samples. 1st ed Darmstadt: GIT Verlag 2001; p. 24-5,50-1
Levey AS, Coresh J, Greene T, Marsh J et al: Expressing the Modification of Diet in Renal Disease Study Equation for Estimating Glomerular Filtration Rate with Standardized Serum Creatinine Values. Clin Chem 2007; 53 (4): 766-72.
Junge W, Wilke B, Halabi A, Klein G. Determination of reference intervals for erum creatinine, creatinine excretion and creatinine clearance with an enzymatic and a modified Jaffé method. Clin Chim Acta 2004; 344: 137-148
Soldin SJ, HicksJM. Pediatric reference range. Washinton : AACC Press, 1995 :50.
Young DS. Effects of Drugs on Clinical laboratory Tests. 5th ed. Volume 1 and 2. Washington, DC: The American Association for Clinical Chemistry Press 2000.
Bakker AJ, Mücke M. Gammopathyinterference in clinical chemistry assays: mechanisms, detection and prevention. ClinChemLabMed 2007;45(9):1240-1243.