Gamma-GT FS (Szasz mod./IFCC stand.)
Gamma-glutamyltransferase (gamma-GT/GGT), also called gamma-glutamyl transpeptidase, is an enzyme present in the liver and bile ducts and is the most sensitive indicator of hepatobiliary disease. Due to the high negative predictive value for these diseases, gamma-GT measurements are widely used to exclude the presence of diseases of liver or biliary origin. Together with other enzymes such as alanine aminotransferase (ALAT), aspartate aminotransferase (ASAT), and cholinesterase, gamma-GT is a potential marker for the differential diagnosis of liver disease.
- Hepatobiliary disease
- History of alcohol consumption
- History of taking addictive drugs, e.g. phenytoin, phenobarbital
- Pancreatitis
- Myocardial infarction (4 – 10 days after)
- Cholestasis
Proline Gamma-GT FS comes in a liquid format which provides convenience for users as no reconstitution is required which helps reduce the risk of misdiagnosis.
Proline Gamma-GT FS reagent is suitable for various third party analyzers such as Abbott, Advia, Cobas, Hitachi, Olympus, Response, TokyoBoeki, and Beckman Coulter. Please contact our technical support at marketing@proline.co.id for further compatibility information on other types of analyzers.
- Kinetic photometric test according to Szasz / Persijn standardized IFCC (International Federation of Clinical Chemistry and Laboratory Medicine)
- Results according to IFCC are obtained using special factors or by using the calibrator values given for the IFCC method.
- No interference: ascorbic acid 30mg/dL, bilirubin 40 mg/dL, hemoglobin 150mg/dL, and lipemia up to 2000mg/dL triglycerides
- Measurement linearity reached 1200 U/L, with a lower limit of detection 2 U/L
| No. Catalog | R1 | R2 | Kit Size |
| 1 2801 99 10 022 | 5 X 20 mL | 1 X 25 mL | Multi Purpose Kit |
| 1 2801 99 10 027 | 2 X 100 mL | 2 X 25 mL | Multi Purpose Kit |
| 1 2801 99 10 181 | 4 X 36 mL | 4 X 9 mL | TMS50i |
| 1 2801 99 10 191 | 4 X 36 mL | 4 X 9 mL | TMS24i |
| 1 2801 99 10 591 | 4 X 60 mL | 4 X 15 mL | Mindray |
| 1 2801 99 10 914 | 6 X 60 mL | 6 X 15 mL | Hitachi 917 |
| 1 2801 99 10 920 | 4 X 34 mL | 4 X 10 mL | Proline® R-910 |
| 1 2801 99 10 921 | 4 X 21 mL | 4 X 6 mL | Proline® R-910 |
| 1 2801 99 10 951 | 6 X 36 mL | 6 X 9 mL | Advia |
| 1 2801 99 10 965 | 6 X 25 mL | 6 X 6 mL | Other Automated Instrument |
| Szasz Modified | ||
| Women | < 32 U/L | < 0.53 µkat/L |
| Men | < 49 U/L | < 0.82 µkat/L |
| IFCC | ||
| Women | < 38 U/L | < 0.63 µkat/L |
| Men | < 55 U/L | < 0.92 µkat/L |
| Children/ Teenager | Women[U/L] | Women[µkat/L] | Men[U/L] | Men[µkat/L] |
| 1 day – 6 month | 15 – 132 | 0.250 – 2.20 | 12 – 122 | 0.200 – 2.03 |
| 6 – 12 year | 1 – 39 | 0.017 – 0.651 | 1 – 39 | 0.017 – 0.651 |
| 1 – 12 year | 4 – 22 | 0.067 – 0.367 | 3 – 22 | 0.050 – 0.367 |
| 13 – 18 year | 4 – 24 | 0.067 – 0.401 | 2 – 42 | 0.033 – 0.701 |
Each laboratory should check if the reference ranges are transferable to its own patient population and determine own reference ranges if necessary
- Persijn JP, van der Silk W. A new method for the determination of gamma-glutamyltransferase
in serum. J Clin Chem Clin Biochem 1976; 14: 421-7. - Schumann G, Bonora R, Ceriotti F, Fιrard G et al. IFCC primary reference procedure for the
measurement of catalytic activity concentrations of enzymes at 37 °C. Part 5: Reference
procedure for the measurement of catalytic concentration of γ-glutamyltransferase. Clin
Chem Lab Med 2002; 40: 734-8. - Guder WG, Zawta B et al. The Quality of Diagnostic Samples. 1 ed. Darmstadt: GIT Verlag;
2001; p. 30-1 - Fischbach F, Zawta B. Age-dependent reference limits of several enzymes in plasma at
different measuring temperatures. Klin Lab 1992; 38: 555-61.
- Thomas L. Clinical Laboratory Diagnostics. 1 ed. Frankfurt: TH-Books
Verlagsgesellschaft;1998. p. 80-6.
- Young DS. Effects of Drugs on Clinical Laboratory Tests. 5th. ed. Volume 1 and 2.
Washington, DC: The American Association for Clinical Chemistry Press, 2000.
- Szasz G. Gamma-Glutamyltranspeptidase. In: Bergmeyer HU. Methoden der enzymatischen
Analyse. Weinheim: Verlag Chemie, 1974. p. 757.
- Bakker AJ, Mόcke M. Gammopathy interference in clinical chemistry assays: mechanisms,
detection and prevention. ClinChemLabMed 2007;45(9):1240-1243.
- Liver disease
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- Phone. +6221 8984 2722
- WhatsApp. +62 815 1359 2626
- Email. marketing@proline.co.id
Contact our Technical Assistance team for further assistance with product specifications, services and other technical documents.
- Phone. +6221 8984 2722
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- Email. technical.support@prodis.co.id