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LDL-C Direct FS

Product No. : 1 4131

Description

Cholesterol is a component of cell membranes and serves also as a precursor for biosynthesis e.g. steroid hormones and bile acids. In plasma, cholesterol is transported by lipoproteins, forming lipid-apolipoprotein complexes. There are four types of lipoproteins: high density lipoprotein (HDL), low density lipoprotein (LDL), very low density lipoprotein (VLDL) and chylomicrons. LDL functions to carry cholesterol to peripheral cells, while HDL is responsible for taking cholesterol from body cells. Four different kinds of lipoproteins show different relationships for coronary atherosclerosis.

LDL cholesterol contributes to the formation of atherosclerotic plaques within the arterial intima and is strongly associated with coronary heart disease (CHD) and associated mortality. Even with total cholesterol within the normal range, elevated LDL cholesterol concentrations indicate high risk. HDL cholesterol has a protective effect that inhibits plaque formation and shows an inverse relationship with the prevalence of CHD. In fact, a low HDL cholesterol value is an independent risk factor. Determination of individual total cholesterol (TC) levels is used for screening purposes whereas for better risk assessment it is necessary to carry out additional measurements of HDL cholesterol and LDL cholesterol.

In the last few years, several controlled clinical trials using diet, lifestyle changes, and/or different drugs (especially HMG CoA reductase inhibitors [statins]) have demonstrated that lowering total cholesterol and LDL cholesterol levels reduces CHD risk drastically.

Increased in

  • Dislipoproteinemia
  • Atherosclerosis risk assessment

Feature

Fluid-stable, ready-to-use reagent

Proline LDL-C Direct FS comes in liquid format that provide convinience for the user as the reconstitution is not needed which aids in reducing the risk of misdiagnosis.

Open system reagent

Proline LDL-C Direct FS reagent is suitable for a wide range of third-party analyzers such as Abbott, Advia, Cobas, Hitachi, Olympus, Respons, TokyoBoeki, and Beckman Coulter. Please reach our technical support at marketing@proline.co.id for further compatibility information on other types of the analyzer. 

Specification

  • Enzymatic test for direct measurement of LDL cholesterol
  • No interference: ascorbic acid 50 mg/dL, bilirubin 50 mg/dL, unconjugated bilirubin 40 mg/dL,
    hemoglobin 500 mg/dL, and lipemia 600 mg/dL triglycerides
  • Linearity measurement 400 mg/dL with limit of detection 1 mg/dL

Calibrator

Control

Kit Lines

Catalog No. R1 R2 Kit Lines
1 4131 99 10 022 5 X 20 mL 1 X 25 mL Multi Purpose Kit (MPK)
1 4131 99 10 025 3 X 80 mL 1 X 60 mL Multi Purpose Kit (MPK)
1 4131 99 10 029 3 X 200 mL 1 X 150 mL Multi Purpose Kit (MPK)
1 4131 99 10 920 4 X 38 mL 4 X 11 mL Proline® R-910
1 4131 99 10 921 4 X 23 mL 4 X 7 mL Proline® R-910
1 4131 99 10 181 4 X 36 mL 4 X 9 mL TMS 50i
1 4131 99 10 191 4 X 36 mL 4 X 9 mL TMS 24i

Reference Range

Low density lipoprotein (LDL) is involved in transporting cholesterol to peripheral cells. LDL cholesterol contributes to the formation of atherosclerotic plaques and is strongly associated with coronary heart disease.

Normal ≤ 130 mg/dL ≤ 3.4 mmol/L
Risk limit 130 – 160 mg/dL 3.4 – 4.1 mmol/L
High risk > 160 mg/dL > 4.1 mmol/L

Each laboratory should check whether the reference range can be calculated for its patient population and determine its own reference range if necessary.

Related Product

Related Topic

Category

  • Atherosclerosis
  • Lipid Metabolism

Order information

Reach out to our team for more product and orders information.

  • Phone. +6221 8984 2722
  • WhatsApp. +62 815 1359 2626
  • Email. marketing@proline.co.id

Technical Support

Contact our Technical Assistance team for further assistance with product specifications, services and other technical documents.

  • Phone. +6221 8984 2722
  • WhatsApp. +62 817 9324 884
  • Email. technical.support@prodis.co.id
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