Urea FS
Urea is a nitrogen-containing product of protein catabolism. High levels of urea in the blood are known as hyperuremia or azotemia. Parallel determination of urea and creatinine was performed to differentiate between pre-renal and post-renal azotemia. Pre-renal azotemia, caused by dehydration, increased protein catabolism, treatment with cortisol or decreased renal perfusion, causes an increase in urea levels, while creatinine levels remain within the reference range. In post-renal azotemia, caused by obstruction of the urinary tract, both urea and creatinine levels increase, but creatinine increases to a lesser extent. In kidney disease, urea concentrations are high when the glomerular filtration rate is reduced and protein intake is higher than 200 g/day.
- Impaired kidney function
- Pre-renal azotemia eg. congestive heart failure, shock, etc.
- Post-renal azotemia
- Gastrointestinal bleeding
- High protein diet
- Drugs: corticosteroids, tetracycline
- Insulinoma
- Adrenal cortex insufficiency
- Hypopituitarism
- Extra – pancreatic neoplasm
- Severe liver disease
- Alcohol consumption
- Drugs, eg. sulfonylureas, salicylates, phenformin, insulin, etc.
Proline Urea FS comes in a liquid format which provides convenience for users as no reconstitution is required which helps reduce the risk of misdiagnosis.
Proline Urea FS reagent is suitable for various third party analyzers such as Abbott, Advia, Cobas, Hitachi, Olympus, Response, TokyoBoeki, and Beckman Coulter. Please contact our technical support at marketing@proline.co.id for further compatibility information on other types of analyzers.
- Enzymatic UV test "Urease - GLDH"
- No interference: ascorbic acid 30mg/dL, bilirubin 65mg/dL, hemoglobin 550mg/dL and lipemia up to 1900mg/dL triglycerides
- Measurement linearity reached 300 mg/dL (0.3 - 50 mmol/L), with a lower limit of detection of 3 mg/dL
| No. Catalog | R1 | R2 | Kit Size |
| 1 3021 99 10 022 | 5 X 20 mL | 1 X 25 mL | Multi purpose kit |
| 1 3101 99 10 025 | 3 X 80 mL | 1 X 60 mL | Multi purpose kit |
| 1 3101 99 10 027 | 1 X 100 mL | 2 X 25 mL | Multi purpose kit |
| 1 3101 99 10 029 | 3 X 200 mL | 1 X 150 mL | Multi purpose kit |
| 1 3101 99 10 181 | 4 X 36 mL | 4 X 9 mL | TMS50i |
| 1 3101 99 10 191 | 4 X 36 mL | 4 X 9 mL | TMS24i |
| 1 3101 99 10 591 | 4 X 60 mL | 4 X 15 mL | Mindray |
| 1 3101 99 10 914 | 6 X 60 mL | 6 X 15 mL | Hitachi 917 |
| 1 3101 99 10 920 | 4 X 34 mL | 4 X 10 mL | Proline® R-910 |
| 1 3101 99 10 921 | 4 X 21 mL | 4 X 6 mL | Proline® R-910 |
| 1 3101 99 10 951 | 6 X 25 mL | 6 X 6 mL | Advia |
| 1 3101 99 10 965 | 6 X 25 mL | 6 X 6 mL | Other Automated Instrument |
| Adult | ||
| Global | 17 – 43 mg/dL | 2.8 – 7.2 mmol/L |
| Women < 50 years | 15 – 40 mg/dL | 2.6 – 6.7 mmol/L |
| Women > 50 years |
21 – 43 mg/dL | 3.5 – 7.2 mmol/L |
| Men < 50 years | 19 – 44 mg/dL | 3.2 – 7.3 mmol/L |
| Men > 50 years |
18 – 55 mg/dL | 3.0 – 9.2 mmol/L |
| Children | ||
| 1 – 3 years | 11 – 36 mg/dL | 1.8 – 6.0 mmol/L |
| 4 – 13 years | 15 – 36 mg/dL | 2.5 – 6.0 mmol/L |
| 14 – 19 years | 18 – 45 mg/dL | 2.9 – 7.5 mmol/L |
| BUN in serum/Plasma | ||
| Adult | ||
| Global | 7.94– 20.1 mg/dL | 2.8 – 7.2 mmol/L |
| Women < 50 years |
7.01 – 18.7 mg/dL | 2.6 – 6.7 mmol/L |
| Women > 50 years |
9.81 – 20.1 mg/dL | 3.5 – 7.2 mmol/L |
| Men < 50 years |
8.87 – 20.5 mg/dL | 3.2 – 7.3 mmol/L |
| Men > 50 years |
8.41 - 25.7 mg/dL | 3.0 – 9.2 mmol/L |
| Children | ||
| 1 – 3 years |
5.14 – 16.8 mg/dL | 1.8 – 6.0 mmol/L |
| 4 – 13 years |
7.01 – 16.8 mg/dL | 2.5 – 6.0 mmol/L |
| 14 – 19 years |
8.41 – 21.0 mg/dL | 2.9 – 7.5 mmol/L |
| Urea/Creatinine ratio | 20 – 35 mg/dL | 25 – 40 mmol/L |
| Urea dalam Urine | 26 – 43 g/24h | 0.43 – 0.72 mol/24h |
Each laboratory should check whether the reference range can be calculated for its patient population and determine its own reference range if necessary.
- Thomas L. Clinical Laboratory Diagnostics. 1 ed. Frankfurt: TH-Books Verlagsgesellschaft; 1998. p. 131-7."
- Burtis CA, Ashwood ER, editors. Tietz Textbook of Clinical Chemistry. 3rd ed. Philadelphia: W.B Saunders Company; 1999. p. 1838.
- Talke H, Schubert GE. Enzymatische Harnstoff-bestimmung in Blut und Serum im optischen Test nach Warburg (Enzymatic determination of urea in blood and serum with the optical test according to Warburg). Klin Wschr 1965; 43: 174-5.
- Guder WG, Zawta B et al. The Quality of Diagnostic Samples. 1sted. Darmstadt: GIT Verlag; 2001; p. 48-9, 52-3.
- Young DS. Effects of Drugs on Clinical Laboratory Tests. 5th ed. Volume 1 and 2. Washington, DC: The American Association for Clinical Chemistry Press 2000.on. ClinChemLabMed 2007;45(9):1240-1243.
- Bakker AJ, Mücke M. Gammopathy interference in clinical chemistry assays: mechanisms, detection and prevention. ClinChemLabMed 2007;45(9):1240-1243.
- Kidney disease
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- Phone. +6221 8984 2722
- WhatsApp. +62 815 1359 2626
- Email. marketing@proline.co.id
Contact our Technical Assistance team for further assistance with product specifications, services and other technical documents.
- Phone. +6221 8984 2722
- WhatsApp. +62 817 9324 884
- Email. technical.support@prodis.co.id