PROLINE Uric Acid FS TBHBA
Diagnostic reagent for the quantitative examination of uric acid in serum, plasma, or urine in vitro using a photometric system.
Uric acid is the primary catabolite of purine metabolism, a weak organic acid that mostly exists as monosodium salt under physiological conditions. Functioning as a potent antioxidant, uric acid contributes up to 60% of the antioxidant capacity in human plasma by scavenging free radicals and binding metal ions. Additionally, uric acid is known to have protective effects against neurodegenerative diseases such as Parkinson’s and Alzheimer’s, given that the human brain has a high metabolic rate and is vulnerable to oxidative stress.
Elevated uric acid levels in the blood (hyperuricemia) are closely associated with chronic kidney disease (CKD), where high uric acid levels can accelerate the decline in kidney function and increase the risk of complications such as proteinuria. Hyperuricemia can also be an independent risk factor for CKD progression, particularly in patients with comorbid conditions such as hypertension and diabetes. Therefore, monitoring and controlling uric acid levels are crucial in kidney disease management.
Hyperuricemia is defined as a serum uric acid level of >6.8 mg/dL. Excessive uric acid is a major factor in the formation of monosodium urate (MSU) crystals, influenced by temperature, pH, and ion concentration in serum. At a pH lower than 5.75, as may occur in urine, the dominant form is non-ionized uric acid. The solubility of monosodium urate is approximately 18 times greater than that of uric acid in aqueous solution. This difference in solubility provides a therapeutic basis for alkalizing urine pH above 6.0 in patients who form uric acid stones.
Enzymatic photometric test using TBHBA (2,4,6-tribromo-3-hydroxybenzoic acid).
- Ready-to-use liquid reagent (open-system) without reconstitution
- Excellent linearity and stability performance
- Available in MPK (Multi-Purpose Kit) and dedicated kit
- Compatible with >65 brands of manual and automated clinical chemistry analyzers
| Sample type | Human Serum, plasma heparin or urine |
| Measurement range | 0,07 mg/dL - 20 mg/dL |
| Analysis wavelength | 520 nm, Hg 546 nm, 500-550 nm |
| Analysis mode | End-Point |
| Reagent volume used (analyzer manual) | 250 µL - 1000 µL |
| Sample volume used (analyzer manual) | 10 µL |
| Storage temperature | 2 – 8 °C |
| Open vial stability | 12 months |
| Expiration date | 18 months |
| Control for Uric Acid Reagent | Calibrator for Uric Acid Reagent |
| TruLab N | TruCal U |
| TruLab P | Uric Acid Standard FS |
| Reference Range: | ||||
| Woman | Man | |||
| mg/dL | μmol/L | mg/dL | μmol/L | |
| Serum/Plasma | ||||
| Adult | 2,6 - 6,0 | 155 - 357 | 3,5 - 7,2 | 208 - 428 |
| Children | ||||
| 1 - 30 days | 1,0 - 4,6 | 59 - 271 | 1,2 - 3,9 | 71 - 230 |
| 31 - 365 days | 1,1 - 5,4 | 65 - 319 | 1,2 - 5,6 | 71 - 330 |
| 1 - 3 years | 1,8 - 5,0 | 106 - 295 | 2,1 - 5,6 | 124 - 330 |
| 4 - 6 years | 2,0 - 5,1 | 118 - 301 | 1,8 - 5,5 | 106 - 325 |
| 7 - 9 years | 1,8 - 5,5 | 106 - 325 | 1,8 - 5,4 | 106 - 319 |
| 10 - 12 years | 2,5 - 5,9 | 148 - 348 | 2,2 - 5,8 | 130 - 342 |
| 13 - 15 years | 2,2 - 6,4 | 130 - 9378 | 3,1 - 7,0 | 183 - 413 |
| 16 - 18 years | 2,4 - 6,6 | 142 - 389 | 2,1 - 7,6 | 124 - 448 |
| Urine | ||||
| ≤ 800 mg/24 hours (4.76 mmol/24 hours) under normal diet conditions | ||||
| ≤ 600 mg/24 hours (3.57 mmol/24 hours) under low-purine diet conditions | ||||
- Uric Acid Reagent
- Doos
- Kit insert
- Reagents bottle
- PROLINE. PROLINE Uric Acid FS TBHBA Kit Insert [Update: 13021 01 – Feb 2024/00]
- Barr WG. Uric Acid. In: Walker HK, Hall WD, Hurst JW, editors. Clinical Methods: The History, Physical, and Laboratory Examinations. 3rd edition. Boston: Butterworths; 1990. Chapter 165. Available from: https://www.ncbi.nlm.nih.gov/books/NBK273/
- Firdayanti, F., Idris, S. A., & Arfan, A. (2023). ANALISIS KADAR ASAM URAT SERUM PADA INDIVIDU DENGAN GAGAL GINJAL KRONIK. SENTRI: Jurnal Riset Ilmiah, 2(8), 3251–3257. https://doi.org/10.55681/sentri.v2i8.1264
- Su Woong Jung, Su-Mi Kim, Yang Gyun Kim, Sang-Ho Lee, and Ju-Young Moon. American Journal of Physiology-Renal Physiology 2020 318:6, F1327-F1340. https://doi.org/10.1152/ajprenal.00272.2019
- Brochure : INA
- Nutrition
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