Bilirubin Auto Total FS
Bilirubin is a breakdown product of hemoglobin. Free, unconjugated bilirubin is extremely apolar and nearly insoluble in water, thus forming a complex with albumin for the transport in the blood from the spleen to the liver. In the liver, bilirubin is conjugated with glucuronic acid, and the resulting water-soluble bilirubin glucuronic acid is excreted via the bile ducts.
Hyperbilirubinemia can be caused by increased bilirubin production due to hemolysis (pre-hepatic jaundice), parenchymal damages of the liver (intra-hepatic jaundice) or by occlusion of bile ducts (post-hepatic jaundice). A chronic congenital (predominantly unconjugated) hyperbilirubinemia called Gilbert’s syndrome is quite frequent in the population. High levels of total bilirubin are observed in 60 - 70 % of neonates due to an increased postpartum breakdown of erythrocytes and because of the delayed function of enzymes for bilirubin degradation. Common bilirubin methods detect either total bilirubin or direct bilirubin. Determinations of direct bilirubin measure mainly conjugated, water-soluble bilirubin. Unconjugated bilirubin can therefore be estimated as the difference between total bilirubin and direct bilirubin.
- Neonatal jaundice due to bile duct atresia
- Obstructive jaundice
Proline Bilirubin Auto Total FS comes in a liquid format which provides convenience for users as no reconstitution is required which helps reduce the risk of misdiagnosis.
Proline Bilirubin Auto Total FS reagent is suitable for various third party analyzers such as Abbott, Advia, Cobas, Hitachi, Olympus, Response, TokyoBoeki, and Beckman Coulter. Please contact our technical support at marketing@proline.co.id for further compatibility information on other types of analyzers.
- Photometric test using 2,4-dichloroaniline (DCA)
- No interference: ascorbic acid 30mg/dL, bilirubin 40mg/dL, hemoglobin 500mg/dL, naproxen 1 mmol/L and lipemia up to triglycerides 2000mg/dL
- Measurement linearity reached 30 mg/dL, with a lower limit of detection 0.03 mg/dL
| No. Catalogue | R1 | R2 | Kit Size |
| 1 0811 99 10 022 | 5 X 20 mL | 1 X 25 mL | Multi Purpose Kit |
| 1 0811 99 10 027 | 2 X 100 mL | 2 X 25 mL | Multi Purpose Kit |
| 1 0811 99 10 965 | 6 X 25 mL | 6 X 6 mL | Other Automated Instrument |
| 1 0811 99 10 181 | 4 X 36 mL | 4 X 9 mL | TMS50i |
| 1 0811 99 10 191 | 4 X 36 mL | 4 X 9 mL | TMS24i |
| 1 0811 99 10 591 | 4 X 60 mL | 4 X 15 mL | Mindray |
| 1 0811 99 10 914 | 6 X 60 mL | 6 X 15 mL | Hitachi 917 |
| 1 0811 99 10 920 | 4 X 38 mL | 4 X 11 mL | Proline® R-910 |
| 1 0811 99 10 921 | 4 X 23 mL | 4 X 7 mL | Proline® R-910 |
| 1 0811 99 10 027 | 2 X 100 mL | 2 X 25 mL | Multi Purpose Kit |
| 1 0811 99 10 951 | 6 X 36 mL | 6 X 9 mL | Advia®1800 |
| Neonatal | 24 hours | < 8.8 mg/dL | < 150 µmol/L |
| Day 2 | 1.3 - 11.3 mg/dL | 22 - 193 µmol/L | |
| Day 3 | 0.7 - 12.7 mg/dL | 12 - 217 µmol/L | |
| Day 4 — 6 | 0.1 - 12.6 mg/dL | 1.7 - 216 µmol/L | |
| Children | >1 month | 0.2 - 1.0 mg/dL | 3.4 - 17 µmol/L |
| Adult | 0.1 - 1.2 mg/dL | 1.7 - 21 µmol/L |
Each laboratory should check if the reference ranges are transferable to its own patient population and determine its own reference ranges if necessary.
- Thomas L ed. Clinical Laboratory Diagnostics. 1st ed. Frankfurt: TH-Books Verlagsgesellschaft, 1998: p. 192 - 202.
- Tolman KG, Rej R. Liver function. In: Burtis CA, Ashwood ER, editors. Tietz Textbook of Clinical Chemistry. 3rd ed. Philadelphia: W.B Saunders Company; 1999. p. 1125-77.
- Guder WG, Zawta B et al. The Quality of Diagnostic Samples. 1st ed. Darmstadt: GIT Verlag; 2001; p. 18-9.
- Rand RN, di Pasqua A. A new diazo method for the determination of bilirubin. Clin Chem1962;6:570-8.
- Young DS. Effects of Drugs on Clinical laboratory Tests. 5th ed. Volume 1 and 2. Washington, DC: The American Association for Clinical Chemistry Press 2000.
- Bakker AJ, Mücke M. Gammopathy interference in clinical chemistry assays: mechanisms, detection and prevention. ClinChemLabMed 2007;45(9):1240- 1243.
- Liver Disease
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- Phone. +6221 8984 2722
- WhatsApp. +62 815 1359 2626
- Email. marketing@proline.co.id
Contact our Technical Assistance team for further assistance with product specifications, services and other technical documents.
- Phone. +6221 8984 2722
- WhatsApp. +62 817 9324 884
- Email. technical.support@prodis.co.id