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Creatinine FS

Product Number: 1 1711

Description

Creatinine is a waste product excreted by the kidneys mainly by glomerular filtration. The concentration of creatinine in the plasma of a healthy individual is fairly constant, independent of water intake, exercise, and rate of urine production. Therefore, increased plasma creatinine values always indicate decreased excretion, i.e. impaired kidney function. The creatinine clearance enables a quite good estimation of the glomerular filtration rate (GFR) which allows better detection of kidney diseases and monitoring of renal function. For this purpose, creatinine is measured simultaneously in serum and urine collected over a defined time period.

Increased in

  • Impaired kidney function. Serum creatinine is a more specific indicator of kidney disease than serum urea.
  • Urinary tract obstruction
  • Diabetes
  • Rhabdomyolysis
  • Acromegaly
  • Nephritis

Decreased in

  • Decreased muscle mass (eg muscular dystrophy, myasthenia gravis)

Features

Ready to use reagent.

Proline Creatinine FS comes in a liquid format which provides convenience for users as no reconstitution is required which helps reduce the risk of misdiagnosis.

Open system reagent, compatible with a wide range of instruments.

Proline Creatinine FS reagent is suitable for various third party analyzers such as Abbott, Advia, Cobas, Hitachi, Olympus, Response, TokyoBoeki, and Beckman Coulter. Please contact our technical support at marketing@proline.co.id for further compatibility information on other types of analyzers.

Specification

  • Kinetic test without deproteinization according to the Jaffe method.
  • No interference: ascorbic acid 30mg/dL, bilirubin from 6mg/dL, and hemoglobin 550mg/dL, and triglyceride lipemia 2200mg/dL
  • Measurement linearity reached 18.5 mg/dL, with a lower limit of detection 0.1 mg/dL 

Control

Kit Lines

No. Catalog R1 R2 Kit Size
1 1711 99 10 022 5 X 20 mL 1 X 25 mL Multi Purpose Kit
1 1711 99 10 025 3 X 80 mL 1 X 60 mL Multi Purpose Kit
1 1711 99 10 027 2 X 100 mL 2 X 25 mL Multi Purpose Kit
1 1711 99 10 029 3 X 200 mL 1 X 150 mL Multi Purpose Kit
1 1711 99 10 181 4 X 36 mL 4 X 9 mL TMS50i
1 1711 99 10 191 4 X 36 mL 4 X 9 mL TMS24i
1 1711 99 10 591 4 X 60 mL 4 X 15 mL Mindray
1 1711 99 10 914 6 X 60 mL 6 X 15 mL Hitachi 917
1 1711 99 10 920 4 X 38 mL 4 X 11 mL Proline® R-910
1 1711 99 10 921 4 X 21 mL 4 X 6 mL Proline® R-910
1 1711 99 10 951 6 X 36 mL 6 X 9 mL Advia
1 1711 99 10 965 6 X 25 mL 6 X 6 mL Other Automated Instrument

Reference Range

Serum / Plasma, Jaffé-method not compensated
Women 0.6 – 1.1 mg/dL 53 – 97 µmol/L
Men 0.7 – 1.3 mg/dL 62– 115 µmol/L
Children
Neonatal 0.5 – 1.2 mg/dL 44 – 106 µmol/L
Baby 0.4 – 0.7 mg/dL 35 – 62 µmol/L
Toddler 0.5 – 1.2 mg/dL 44 – 106 µmol/L
     
Serum / Plasma, Jaffé-method compensated
Women 0.5 – 0.9 mg/dL 44 – 80 µmol/L
Men 0.7 – 1.2 mg/dL 62 – 106 µmol/L
     
Children
Neonatal 0.24 – 1.04 mg/dL 21 – 92 µmol/L
Baby 0.17 – 0.42 mg/dL 15 – 37 µmol/L
Toddler 0.24 – 0.87 mg/dL 21 – 77 µmol/L
     
Urine 24 jam
Women 11 – 20 mg/kg/d 97 – 177 µmol/kg/d
Men 14 – 26 mg/kg/d 124 – 230 µmol/kg/d
     
Creatinine clearance
Women 95 – 160 mL/min/1.73 m²
Men 98 – 156 mL/min/1.73 m²
   
Albumine/creatinine ratio (morning urine)
< 30 mg/g Creatinine

Each laboratory should check if the reference ranges are transferable to its own patient population and determine own reference ranges if necessary

Reference

  1. Newman DJ, Price CP. Renal function and nitrogen metabolites. In: Burtis CA, Ashwood ER,editors. Tietz Textbook of Clinical Chemistry. 3rd ed. Philadelphia: W.B Saunders Company;1999. p. 1204-1270.
  2. Thomas L. Clinical Laboratory Diagnostics. 1st ed. Frankfurt: TH-Books Verlagsgesellschaft; 1998. p. 366-74.
  3. Mazzachi BC, Peake MJ, Ehrhardt V. Reference Range and Method Comparison Studies forEnzymatic and Jaffé Creatine Assays in Plasma and Serum and Early Morning Urine. Clin.Lab. 2000; 46: 53-55.
  4. Swanson AF, Swartzentruber M, Nolen PA et al. Multicenter Evaluation of the Boehringer Mannheim Compensated, Rate-Blanked Creatinine/Jaffe Application on BM/Hitachi Systems.Advances in Clinical Diagnostics. 1993. Boehringer Mannheim Corporation.
  5. Guder WG, Zawta B. Recommendations of the Working group on Preanalytical Quality of the German Society for Clinical Chemistry and the German Society for Laboratory Medicine: The Quality of Diagnostic Samples. 1st ed Darmstadt: GIT Verlag 2001; p. 24-5,50-1
  6. Levey AS, Coresh J, Greene T, Marsh J et al: Expressing the Modification of Diet in Renal Disease Study Equation for Estimating Glomerular Filtration Rate with Standardized Serum Creatinine Values. Clin Chem 2007; 53 (4): 766-72.
  7. Junge W, Wilke B, Halabi A, Klein G. Determination of reference intervals for erum creatinine, creatinine excretion and creatinine clearance with an enzymatic and a modified Jaffé method. Clin Chim Acta 2004; 344: 137-148
  8. Soldin SJ, Brugnara C, Wong EC, eds. Pediatric Reference Intervals. 6 ed. AACC Press, 2007:p. 77-78
  9. Schlebusch H, Liappis N, Klein G. Ultrasensitive CRP and Creatinine: Reference intervals from
    infancy to childhood. Clin Chem Lab Med. 2001; 39 Special supplement pp S1-S448; May 2001.PO-T042"
  10. Young DS. Effects of Drugs on Clinical laboratory Tests. 5th ed. Volume 1 and 2. Washington, DC: The American Association for Clinical Chemistry Press 2000.

Related Product

Category

  • Kidney disease

Order information

Reach out to our team for more product and orders information.

  • Phone. +6221 8984 2722
  • WhatsApp. +62 815 1359 2626
  • Email. marketing@proline.co.id

Technical Support

Contact our Technical Assistance team for further assistance with product specifications, services and other technical documents.

  • Phone. +6221 8984 2722
  • WhatsApp. +62 817 9324 884
  • Email. technical.support@prodis.co.id
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