Ferritin is an iron storage protein consisting of 24 subunits that form a hollow sphere up to 4000 iron atoms can be closed. Ferritin containing iron is the main source of iron reserves for every cell and all organisms available for the synthesis of hemoglobin. Variations in serum ferritin are generally closely related to changes in tissue ferritin. Measurement of serum ferritin concentration provides a quantitative determination of mobilizable iron stores. Thus, decreased ferritin levels indicate iron tissue depletion and are very useful in early detection of the most common deficiency anemia for iron disorders in the industrialized world. Elevated serum ferritin concentrations can be suggestive of iron overload in conjunction with an iron storage disorder such as inherited disease or hemochromatosis. It can also be used to clinically evaluate conditions not associated with iron storage including chronic liver disease, infection, inflammation and other malignancies.
- Liver parenchymal damage
- Malignant tumor
- Iron storage anemia
- Chronic blood loss
Proline Ferritin FS comes in a liquid format which provides convenience for users as no reconstitution is required which helps reduce the risk of misdiagnosis.
Proline Ferritin FS reagent is suitable for various third-party analyzers such as Abbott, Advia, Cobas, Hitachi, Olympus, Response, TokyoBoeki, and Beckman Coulter. Please contact our technical support at email@example.com for further compatibility information on other types of analyzers.
- Immunoturbidimetric test (Particle enhanced)
- No effect of prozone was seen up to a concentration of 30000 mg/L ferritin.
- No interference: ascorbic acid 30 mg/dL, bilirubin 60 mg/dL, hemoglobin 1000 mg/dL, lipemia to triglycerides 1400 mg/dL
- Measurement linearity reaches 1000 g/L with a lower limit of detection of 5 g/L
Ferritin is an iron storage protein; decreased levels indicate iron deficiency anemia, increased levels occur eg. in hemochromatosis.
|Men||30 – 400 µg/L|
|Women < 50 years||15 – 150 µg/L|
|Women > 50 years||The approximate reference range for men|
|4 months - 16 years||15 – 150 µg/L|
Each laboratory should check whether the reference range can be calculated for its patient population and determine its own reference range if necessary.
- Wick M, Pingerra W, Lehmann P, Iron metabolism: diagnosis and therapy of anemias, 5th ed, Vienna, New York: Springer Verlag, 2003; p. 151.
- Worwood M. The laboratory assessment of iron status – an update. Clin Chim Acta 1997;259:3-23.
- Kaltwasser JP, Werner E. Diagnosis and clinical evaluation of iron overload. Baillieres Clin Haematol 1989;2;363-89.
- Baynes RD, Cook JD. Current issues in iron deficiency. CurrOpin Hematol 1996;3:145-9.
- Guder WG, Zawta B et al. The Quality of Diagnostic Samples. 1st ed. Darmstadt: GIT Verlag; 2001; p. 28-9.
- Lee MH, Means RT Jr. Extremely elevated serum ferritin levels in a university hospital: associated diseases and clinical significance. Am J Med 1996;98:566-71.
- Young DS. Effects of Drugs on Clinical Laboratory Tests. 5th e d . Volume 1 and 2. Washington DC: The American Association for Clinical Chemistry Press 2000.
- Bakker AJ, Mücke M. Gammopathy interference in clinical chemistry assays: mechanisms, detection and prevention. ClinChemLabMed 2007;45(9):1240-1243.
- Iron Metabolism
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