Ferritin FS

April 26, 2024

Product Number: 1 7059

Description

Ferritin is an iron storage protein consisting of 24 subunits that form a hollow sphere up to 4000 iron atoms can be closed. Ferritin containing iron is the main source of iron reserves for every cell and all organisms available for the synthesis of hemoglobin. Variations in serum ferritin are generally closely related to changes in tissue ferritin. Measurement of serum ferritin concentration provides a quantitative determination of mobilizable iron stores. Thus, decreased ferritin levels indicate iron tissue depletion and are very useful in early detection of the most common deficiency anemia for iron disorders in the industrialized world. Elevated serum ferritin concentrations can be suggestive of iron overload in conjunction with an iron storage disorder such as inherited disease or hemochromatosis. It can also be used to clinically evaluate conditions not associated with iron storage including chronic liver disease, infection, inflammation and other malignancies.

Increased in

Liver parenchymal damage
Malignant tumor

Decreased in

Iron storage anemia
Chronic blood loss
Malabsorption

Features

Ready to use reagent.

Proline Ferritin FS comes in a liquid format which provides convenience for users as no reconstitution is required which helps reduce the risk of misdiagnosis.

Open system reagent, compatible with a wide range of instruments.

Proline Ferritin FS reagent is suitable for various third-party analyzers such as Abbott, Advia, Cobas, Hitachi, Olympus, Response, TokyoBoeki, and Beckman Coulter. Please contact our technical support at marketing@proline.co.id for further compatibility information on other types of analyzers.

Specification

Immunoturbidimetric test (Particle enhanced)
No effect of prozone was seen up to a concentration of 30000 mg/L ferritin.
No interference: ascorbic acid 30 mg/dL, bilirubin 60 mg/dL, hemoglobin 1000 mg/dL, lipemia to triglycerides 1400 mg/dL
Measurement linearity reaches 1000 g/L with a lower limit of detection of 5 g/L

Calibrator

TruCal Ferritin

Control

TruLab Protein

Kit Lines

No. Catalog	R1	R2	Kit Size
1 7059 99 10 964	6 X 8 mL	6 X 8 mL	Other Automated Instrument
1 7059 99 10 309	3 X 20 mL	3 X 10 mL	Multi Purpose Kit
1 7059 99 10 930	3 X 20 mL	3 X 10 mL	Hitachi 704/717/902/911/912/917
1 7059 99 10 935	1 X 20 mL	1 X 10 mL	Hitachi 704/717/902/911/912/917

Reference Range

Ferritin is an iron storage protein; decreased levels indicate iron deficiency anemia, increased levels occur eg. in hemochromatosis.

Adult
Men	30 – 400 µg/L
Women < 50 years	15 – 150 µg/L
Women > 50 years	The approximate reference range for men

Children
4 months - 16 years	15 – 150 µg/L

Each laboratory should check whether the reference range can be calculated for its patient population and determine its own reference range if necessary.

References

Wick M, Pingerra W, Lehmann P, Iron metabolism: diagnosis and therapy of anemias, 5th ed, Vienna, New York: Springer Verlag, 2003; p. 151.
Worwood M. The laboratory assessment of iron status – an update. Clin Chim Acta 1997;259:3-23.
Kaltwasser JP, Werner E. Diagnosis and clinical evaluation of iron overload. Baillieres Clin Haematol 1989;2;363-89.
Baynes RD, Cook JD. Current issues in iron deficiency. CurrOpin Hematol 1996;3:145-9.
Guder WG, Zawta B et al. The Quality of Diagnostic Samples. 1st ed. Darmstadt: GIT Verlag; 2001; p. 28-9.
Lee MH, Means RT Jr. Extremely elevated serum ferritin levels in a university hospital: associated diseases and clinical significance. Am J Med 1996;98:566-71.
Young DS. Effects of Drugs on Clinical Laboratory Tests. 5th e d . Volume 1 and 2. Washington DC: The American Association for Clinical Chemistry Press 2000.
Bakker AJ, Mücke M. Gammopathy interference in clinical chemistry assays: mechanisms, detection and prevention. ClinChemLabMed 2007;45(9):1240-1243.