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Cholesterol FS 10'

Product Number: 1 1300

Description

Cholesterol is a component off cell membranes and a precursor for steroid hormones and bile acids synthesized by body cells and absorbed with food. Cholesterol is transported in plasma via lipoproteins, namely complexes between lipids and apolipoproteins. There are four classes of lipoproteins: high-density lipoproteins (HDL), low-density lipoproteins (LDL), very-low-density lipoproteins (VLDL), and chylomicrons. While LDL is involved in cholesterol transport to the peripheral cells, HDL is responsible for the cholesterol uptake from the cells. The four different lipoprotein classes show a distinct relationship to coronary atherosclerosis. LDL-cholesterol (LDL-C) contributes to atherosclerotic plaque formation within the arterial intima and is strongly associated with coronary heart disease (CHD) and related mortality. Even with total cholesterol within the normal range, an increased concentration of LDL-C indicates high risk.

HDL-C has a protective effect impeding plaque formation and shows an inverse relationship to CHD prevalence. In fact, low HDL-C values constitute an independent risk factor. The determination of the individual total cholesterol (TC) level is used for screening purposes while for a better risk assessment it is necessary to measure additionally HDL-C and LDL-C. In the last few years, several controlled clinical trials using diet, lifestyle changes and/or different drugs (especially HMG CoA reductase inhibitors [statins]) have demonstrated that lowering total cholesterol and LDL-C levels reduce drastically CHD risk

Increased in

  • Familial (inherited) hypercholesterolemia
  • Biliary obstruction
  • Nephrotic syndrome
  • Hypothyroidism
  • Pregnancy

Decreased in

  • Severe hepatic insufficiency
  • Malnutrition
  • Hyperthyroidism
  • Chronic anemia
  • Waldenstrom macroglobulinemia
  • Thyroiditis

Features

Ready to use reagent.

Proline Cholesterol FS 10' comes in a liquid format which provides convenience for users as no reconstitution is required which helps reduce the risk of misdiagnosis.

Open system reagent, compatible with a wide range of instruments.

Proline Cholesterol FS 10' reagent is suitable for various third party analyzers such as Abbott, Advia, Cobas, Hitachi, Olympus, Response, TokyoBoeki, and Beckman Coulter. Please contact our technical support at marketing@proline.co.id for further compatibility information on other types of analyzers.

Specification

  • Optimal UV Test according to IFCC (International Federation of Clinical Chemistry and Laboratory Medicine)
  • No interference: ascorbic acid 6mg/dL, bilirubin 25mg/dL and hemoglobin 230mg/dL
  • Measurement linearity reached 750 mg/dL, with a lower limit of detection of 1 mg/dL

Control

Kit Lines

No. Catalogue R1 Kit Size
1 1300 99 10 022  5 X 20 mL Multi Purpose Kit
1 1300 99 10 025 3 X 80 mL Multi Purpose Kit
1 1300 99 10 027 4 X 62,5 mL Multi Purpose Kit
1 1300 99 10 029 3 X 200 mL Multi Purpose Kit
1 1300 99 10 182 4 X 60 mL TMS50i
1 1300 99 10 192 4 X 60 mL TMS24i
1 1300 99 10 592 4 X 60 mL Mindray
1 1300 99 10 915 6 X 60 mL Hitachi 917
1 1300 99 10 923 4 X 34 mL Proline® R-910
1 1300 99 10 961 6 X 25 mL Other Automated Instrument
1 1300 99 10 952 6 X 40 mL Advia

Reference Range

Total Desirable ≤ 200 mg/dL 5.2 mmol/L
Borderline high risk 200 – 240 mg/dL 5.2 – 6.2 mmol/L
High risk > 240 mg/dL > 6.2 mmol/L

Each laboratory should check whether the reference range can be calculated for its patient population and determine its own reference range if necessary.

References

  1. Rifai N, Bachorik PS, Albers JJ. Lipids, lipoproteins and apolipoproteins. In: rd Burtis CA, Ashwood ER, editors. Tietz Textbook of Clinical Chemistry. 3 ed. Philadelphia: W.B Saunders Company; 1999. p. 809-61.
  2. Recommendation of the Second Joint Task Force of European and other Societies on Coronary Prevention. Prevention of coronary heart disease in clinical practice. Eur Heart J 1998; 19: 1434-503.1.
  3. Artiss JD, Zak B. Measurement of cholesterol concentration. In: Rifai N, Warnick GR, Dominiczak MH, eds. Handbook of lipoprotein testing. Washington: AACC Press, 1997: p. 99-114.
  4. Deeg R, Ziegenhorn J. Kinetic enzymatic method for automated determination of total cholesterol in serum. Clin Chem 1983; 29: 1798-802.
  5. Schaefer EJ, McNamara J. Overview of the diagnosis and treatment of lipid disorders. In: Rifai N, Warnick GR, Dominiczak MH, eds. Handbook of lipoprotein testing. Washington: AACC press, 1997: p. 25-48.
  6. Guder WG, Zawta B et al. The Quality of Diagnostic Samples. 1 ed. Darmstadt: GIT Verlag; 2001. p. 22-3.
  7. Young DS. Effects of Drugs on Clinical laboratory Tests. 5th ed. Volume 1 and 2. Washington, DC: The American Association for Clinical Chemistry Press 2000.
  8. Bakker AJ, Mücke M. Gammopathy interference in clinical chemistry assays: mechanisms, detection and prevention. ClinChemLabMed 2007;45(9):1240-1243.

Category

  • Lipid Metabolism
  • Atherosclerosis

Order information

Reach out to our team for more product and orders information.

  • Phone. +6221 8984 2722
  • WhatsApp. +62 815 1359 2626
  • Email. marketing@proline.co.id

Technical Support

Contact our Technical Assistance team for further assistance with product specifications, services and other technical documents.

  • Phone. +6221 8984 2722
  • WhatsApp. +62 817 9324 884
  • Email. technical.support@prodis.co.id
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