HDL-C Direct FS
Cholesterol is a component of cell membranes and a precursor for steroid hormones and bile acids synthesized by body cells and absorbed with food. Cholesterol is transported in plasma via lipoproteins, namely complexes between lipids and apolipoproteins. There are four classes of lipoproteins: high density lipoproteins (HDL), low density lipoproteins (LDL), very low density lipoproteins (VLDL) and chylomicrons. While LDL is involved in the cholesterol transport to the peripheral cells, HDL is responsible for the cholesterol uptake from the cells. The four different lipoprotein classes show distinct relationship to coronary atherosclerosis.
LDL cholesterol contributes to atherosclerotic plaque formation within the arterial intima and is strongly
associated with coronary heart disease (CHD) and related mortality. Even with total cholesterol within the normal range an increased concentration of LDL cholesterol indicates high risk. HDL cholesterol has a protective effect impeding plaque formation and shows an inverse relationship to CHD prevalence. In fact, low HDL cholesterol values constitute an independent risk factor. The determination of the individual total cholesterol (TC) level is used for screening purposes while for a better risk assessment it is necessary to measure additionally HDL cholesterol and LDL cholesterol.
In the last few years several controlled clinical trials using diet, life style changes and/or different drugs (especially HMG CoA reductase inhibitors [statins]) have demonstrated that lowering total cholesterol and LDL cholesterol levels reduce drastically CHD risk.
- Tangier disease
- Atherosclerosis risk assessment
- Homogeneous method for direct measurement of HDL-cholesterol
- No interference: ascorbic acid 60 mg/dL, bilirubin 40 mg/dL, unconjugated bilirubin 60 mg/dL, hemoglobin 1000 mg/dL, and lipemia to triglycerides 1000 mg/dL
- Measurement linearity reached 200 mg/dL with a lower limit of detection of 3 mg/dL
|No. Catalogue||R1||R2||Kit Size|
|1 3561 99 10 022||5 X 20 mL||1 X 25 mL||Multi Purpose Kit|
|1 3561 99 10 025||3 X 80 mL||1 X 60 mL||Multi Purpose Kit|
|1 3561 99 10 029||3 X 200 mL||1 X 150 mL||Multi Purpose Kit|
|1 3561 99 10 920||4 X 38 mL||4 X 11 mL||Proline® R-910|
|1 3561 99 10 921||4 X 23 mL||4 X 7 mL||Proline® R-910|
|1 3561 99 10 181||4 X 36 mL||4 X 9 mL||TMS 50i|
|1 3561 99 10 191||4 X 36 mL||4 X 9 mL||TMS 24i|
High-density lipoprotein (HDL) is involved in the uptake of cholesterol from cells. HDL cholesterol has a protective effect that inhibits plaque formation and shows an inverse relationship with the prevalence of CHD.
A number of factors contribute to low HDL cholesterol levels: e.g. overweight and obesity, smoking, physical activity, drugs such as beta-blockers and progestational agents, genetic factors.
|National Cholesterol Education Program Guidelines (NCEP):|
|Major risk factor for CHD||< 40 mg/dL (< 1.04 mmol/L)|
|"Negative" risk factor for CHD||≥ 60 mg/dL (≥ 1.55 mmol/L)|
Each laboratory should check whether the reference range can be calculated for its patient population and determine its own reference range if necessary.
For diagnostic purposes, outcomes should always be assessed against the patient's medical history, clinical examination, and other findings.
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