Creatine kinase (CK) is an enzyme consisting of isoenzymes mainly in muscle (CK-M) and brain (CK-B). CK is found in the human body in dimeric form as CK-MM, CK-MB, CK-BB as a macro-enzyme. The CK-MB measurement is a specialized test for detecting cardiac muscle damage and, therefore, is used for the diagnosis and monitoring of myocardial infarction.
Proline CK-MB FS comes in a liquid format which provides convenience for users as no reconstitution is required which helps reduce the risk of misdiagnosis.
Proline CK-MB FS reagent is suitable for various third party analyzers such as Abbott, Advia, Cobas, Hitachi, Olympus, Response, TokyoBoeki, and Beckman Coulter. Please contact our technical support at firstname.lastname@example.org for further compatibility information on other types of analyzers.
- The UV optimization assay was optimized based on DGKC and IFCC homogeneous methods for CK by inhibiting the CK-M isoenzyme by monoclonal antibodies.
- No interference: ascorbic acid 30 mg/dL, bilirubin 25 mg/dL, hemoglobin 10mg/dL, lipemia to triglycerides 1400mg/dL
- Measurement linearity reaches 2000 U/L with a lower limit of detection of 4.3 U/L
|No. Catalog||R1||R2||Kit Size|
|1 1641 99 10 021||5 X 20 mL||1 X 25 mL||Multi Purpose Kit|
|1 1641 99 10 026||5 X 80 mL||1 X 100 mL||Multi Purpose Kit|
|1 1641 99 10 921||4 X 21 mL||4 X 60 mL||Proline® R-910|
|1 1641 99 10 930||4 X 20 mL||2 X 10 mL||Hitachi 704/717/902/911/912/917
|1 1641 99 10 964||6 X 16 mL||6 X 6 mL||Other Automated Instrument|
The measurement of creatine kinase (CK) is specific for detecting heart muscle damage and is used for the diagnosis and monitoring of myocardial infarction.
| < 24 U/L
|| < 0.4 µkat/L
Each laboratory should check if the reference ranges are transferable to its own patient population and determine own reference ranges if necessary.
- Stein W. Creatine kinase (total activity), creatine kinase isoenzymes and variants. In: Thomas L, ed. Clinical laboratory diagnostics. Frankfurt: TH-Books Verlagsgesellschaft;1998.p.71–80.
- Moss DW, Henderson AR. Clinical enzymology. In: Burtis CA, Ashwood ER, editors. Tietz Textbook of Clinical Chemistry. 3rd ed. Philadelphia: W.B Saunders Company; 1999. p. 617–721.
- Würzburg U, Hennrich N, Orth HD, Lang H. Quantitative determination of Recommendations of the German Society for Clinical Chemistry. Standardization of methods for estimation of enzyme activities in biological fluids: standar method for determination of creatinine kinase activity. J. Clin Chem Clin Biochem 1977;15: 255-60
- Shumann G, Bonora R, Ceriotti F, Férard G et al. IFCC primary reference procedure for the measurement of catalytic activity concentrations of enzymes at 37 °C. Part 5: Reference procedure for the measurement of catalytic concentration of creatine kinase. Clin Chem Lab Med 2002;40:635-42.
- Stein W. Strategie der klinisch-chemischen Diagnostik des frischen
Myokardinfarkts. Med Welt 1985:36:572-7.
- Myocardial infarction redefined – a consensus document of the Joint European society of Cardiology/America College of Cardiology Committee for the redefinition of myocardial Infarction. Eur Heart J 2000;21:1502-13.
- Guder WG, Zawta B et al. The Quality of Diagnostic Samples. 1st ed. Darmstadt: GIT Verlag; 2001; p. 24-5.
- Young DS. Effects of Drugs on Clinical Laboratory Tests. 5th ed. Volume 1 and 2.
Washington, DC: The American Association for Clinical Chemistry Press 2000.
- Bakker AJ, Mücke M. Gammopathy interference in clinical chemistry assays:
mechanisms, detection and prevention. ClinChemLab 2007;45(9):1240–1243.
- Heart disease
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